Searchable abstracts of presentations at key conferences in endocrinology

ea0056p535 | Obesity | ECE2018

Effect of the Andean plant Lampaya on NF-κB and JNK phosphorylation in human macrophages treated with palmitic acid.

Ormazabal Paulina , Cifuentes Mariana , Fuentes Cecilia , Paredes Adrian , Morales Glauco

Background: Adipose tissue dysfunction occurring in obesity leads to a low grade chronic inflammatory state. Fat tissue from obese individuals has a high infiltration rate of macrophages contributing to the development of obesity-related inflammation. At the cellular level, inflammation can be triggered by the activation (phosphorylation) of NF-κB as well as JNK. On the other hand, palmitic acid (PA) is a saturated fatty acid found elevated in plasma from obese subjects a...

ea0081p86 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effect of an extract of the Andean plant Lampaya on insulin signaling and proinflammatory markers in human adipocytes treated with palmitic acid

Ormazabal Paulina , Yuri Gabriela , Villagran Isidora , Cerda Alexis , Cifuentes Mariana , Paredes Adrian , Morales Glauco

Background: Obesity is strongly associated with a state of chronic low grade systemic inflammation and insulin resistance (IR). IR at the molecular level may be defined as a diminished activation of the metabolic phosphatidylinositol-3-kinase (PI3K)/Akt pathway of insulin. On the other hand, inflammatory response may be activated by NF-κB. Subject with obesity have elevated plasma levels of saturated fatty acids, such as palmitic acid (PA), which triggers insulin and infl...

ea0037gp.06.05 | Reproduction: Female and PCOS | ECE2015

Cytokine expression in SAT and VAT from PCOS patients and control women; possible proinflammatory effect of testosterone depending on BMI – a preliminary report

Crisosto Nicolas , Echiburu Barbara , Perez-Bravo Francisco , Flores Cristian , Fuentes Cecilia , Cifuentes Mariana , Orellana Omar , Maluenda Fernando , Sir-Petermann Teresa

Context: Insulin resistance is an important component of polycystic ovary syndrome (PCOS). Local cytokine production in adipose tissue increases local insulin resistance. The effect of testosterone on local adipose tissue cytokine production has not been explored thoroughly.Aim: To evaluate cytokine expression in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from PCOS and control women and evaluate the response to testosterone on th...