Searchable abstracts of presentations at key conferences in endocrinology

ea0016p341 | Endocrine tumours | ECE2008

Association of genetic variants of somatostatin receptor 5 with acromegaly

Klovins Janis , Kapa Ivo , Balcere Inga , Ciganova Darja , Nikitina-Zake Liene , Schioth Helgi , Pirags Valdis

Full gene coding sequence of somatostatin receptor 5 and 2000 bp of upstream region was estimated using direct sequencing in 28 patients with acromegaly and 97 controls. Total 19 polymorphisms were identified (SNP1-19) and possible haplotypes were reconstructed. From all polymorphisms found silent substitution SNP15 was significantly associated with acromegaly as compared with control group (P=0.005). Another substitution SNP17 involves the amino acid change from prolin...