Searchable abstracts of presentations at key conferences in endocrinology

ea0026p356 | Steroid metabolism | ECE2011

Hormonal parameters and sex hormone receptor gene polymorphisms in males with autoimmune diseases

Doukas Charalampos , Saltiki Katerina , Terzidis Kostas , Mantzou Aimily , Sarika Lida , Cimponeriu Andriana , Sfikakis Petros , Alevizaki Maria

Introduction: Autoimmune disease (AD) is more common in women than in men. Sex hormones may play a role. Sex hormone receptors (SHR) are expressed in cells of the autoimmune system. We investigated the possible role of hormonal parameters and of common gene polymorphisms of the estrogen receptor alpha (ESR1), beta (ESR2) and androgen receptor (AR) in the presence of AD in men.Methods: In total 227 men were studied; 125 had at least o...

ea0020p669 | Steroid Receptors | ECE2009

Androgen receptor gene CAG(n) repeat polymorphism and coronary artery disease (CAD) in women

Alevizaki Maria , Saltiki Katerina , Cimponeriu Adriana , Garofalaki Maria , Mantzou Emily , Stamatelopoulos Kimon

Objective: Androgen may be detrimental for vascular health in women. Sensitivity to androgen is influenced by the CAG repeat length of the androgen receptor (AR) gene. We investigated possible associations between the CAG repeat polymorphism with the severity of CAD in women undergoing coronary angiography.Methods: We examined 131 postmenopausal women (45–88 years). CAD severity was assessed by the number of coronary vessels with >50% stenosis. ...

ea0014oc6.6 | Cardiovascular endocrinology | ECE2007

The importance of the TAAAA(n) alleles at the SHBG gene promoter for the severity of cardiovascular disease in women

Saltiki Katerina , Xita Nectaria , Cimponeriu Adriana , Kanakakis Ioannis , Mantzou Emily , Doukas Charalambos , Georgiou Ioannis , Alevizaki Maria

Objective: Androgen may be detrimental in the development of coronary artery disease (CAD) in women. We investigated possible associations between the (TAAAA)n polymorphism of sex hormone binding globulin (SHBG) gene promoter, which influences transcriptional efficiency of the SHBG gene and the severity of CAD in women.Methods: One hundred and twenty women (37–82 yrs), undergoing coronary angiography. CAD severity, history of angina, myocardial infa...

ea0011p332 | Diabetes, metabolism and cardiovascular | ECE2006

The severity of cardiovascular disease in women is modified by estrogen receptor alpha polymorphic variants

Alevizaki M , Saltiki K , Kanakakis I , Cimponeriu A , Alevizaki C , Georgiou I , Anastasiou E

Impaired estrogen (E2) action is important for cardiovascular disease (CAD) in both men and women. Associations of CAD with estrogen receptor polymorphisms, which may influence sensitivity to E2 have been reported for men but have not been confirmed for women. The aim of the present study was to investigate the association of estrogen receptor common polymorphisms with the severity of coronary disease in women undergoing coronary angiography.Estrogen rec...