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ea0073oc10.2 | Oral Communications 10: Thyroid | ECE2021

NTRK fusion genes in thyroid cancer

Pekova Barbora , Sykorova Vlasta , Mastnikova Karolina , Vaclavikova Eliska , Moravcova Jitka , Petr Vlcek , Lastuvka Petr , Taudy Milos , Cisel Rami , Bavor Petr , Kodetova Daniela , Kodetova Martin , Drozenova Jana , Kodetova Jaromir , Hrabal Petr , Vcelak Josef , Bendlova Bela

ObjectivesRearrangement involving one of the neurotrophic-tropomyosin receptor kinase (NTRK) genes belonging to the NTRK family represents a significant oncogenic event in thyroid cancer (TC). Recently, there has been a growing interest in testing and characterizing NTRK fusion genes because they are therapeutically targetable. This study aimed to determine a frequency, clinical and histopathological features of a large cohort ...