Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep1161 | Clinical Cases–Pituitary/Adrenal | ECE2015

Pasireotide - the last treatment option in Cushing's disease - case report

Galesanu Corina , Condrea Adrian , Niculescu Dan , Florescu Alexandru , Buzduga Catalin , Moisii Liliana , Ciubotaru Vasile

Introduction: The most common cause of Cushing’s disease is ACTH secreting tumours of the pituitary gland. It is associated with high morbidity and mortality. Pasireotide, a potential therapy, has a unique, broad somatostatin-receptor–binding profile, with high binding affinity for somatostatin-receptor subtype 5.Case report: We present the a 40-years-old man diagnosed in 2005 with Cushing’s Disease for which a left adrenalectomy was perfo...

ea0014p486 | (1) | ECE2007

Persistent fever after surgical removal of a craniopharyngioma: diagnosis pitfalls and therapeutic difficulties

Trifanescu Raluca Alexandra , Gheorghiu Monica Livia , Ogrezean Irina , Ciubotaru Vasile , Preotescu Daniela , Fahlbusch Rudolf , Coculescu Mihail

Background: Thermoregulatory disorders after neurosurgery of craniopharingyomas were seldom reported.Aim: To present the difficulties of etiologic diagnosis and treatment of a persistent febrile syndrome in a patient with surgically removed craniopharyngioma.Patient and methods: A 34 years old man with a giant craniopharyngioma situated in the basal-anterior part of the third ventricle is reported. Anterior pituitary hormones were ...

ea0049ep1063 | Pituitary - Clinical | ECE2017

“Toxic” Goiter Reveals Cushing’s Disease

Musat Madalina , Hortopan Dan , Oprea Luciana , Duceac Andreea , Manda Dana , Caragheorgheopol Andra , Iordachescu Carmen , Tupea Claudiu , Ciubotaru Vasile

Case presentation: Mrs. S presented in an endocrine clinic for fatigue, weight loss, restlessness and goiter. She was obese with a BMI of 51 kg/mp, hypertensive and had a medium size, nontender goiter. Lab test revealed hyperglycaemia, suppressed TSH (<0.03mUI/L), on two separate occasions, mid-normal fT4 and T3. Thyroid ultrasound revealed multinodular goiter. A diagnosis of polynodular goiter with subclinical hyperthyroidism was made and patient was commenced on thiamazo...

ea0049ep1073 | Pituitary - Clinical | ECE2017

Aggressive macroprolactinoma – exception to the rule

Belceanu Alina Daniela , Constantinescu Georgiana , Crumpei Iulia , Bursuc Anamaria , Rotariu Daniel , Constantinescu Aurora , Ciubotaru Vasile , Preda Cristina , Vulpoi Carmen

Background: Prolactinoma is the most frequent pituitary tumour. However, peculiar aspects may induce difficulties in their evolution and management. Malignant prolactinoma is exceptionally rare and it cannot be diagnosed on histological grounds alone. We report the case of a recurrent, possibly malignant macroprolactinoma.Case report: 46 years old female, addressed for bitemporal hemianopia, without other clinical signs. MRI confirmed a pituitary macroad...

ea0032p857 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Similar response to therapy of pituitary adenomas with and without SOX2-expressing cells

Coculescu Mihail , Campean Anca , Stancu Cristina , Capatina Cristina , Livia Gheorghiu Monica , Caragheorgheopol Andra , Hortopan Dan , Ciubotaru Vasile , Raica Marius

Introduction: SOX2 is an early developmental transcription factor and a marker for pituitary progenitor cells.The study aimed to investigate if the pituitary adenomas with positive SOX2 immunoreactivity shows a different response to therapy as compared with controls.Patients and methods: We investigated 15 pituitary macroadenomas, eight with SOX2 immunoreactivity (SOX2+) and seven without (SOX2−) (controls); five were GH prod...

ea0031p266 | Pituitary | SFEBES2013

Long-term results after treatment of craniopharyngioma: experience with 46 adult patients

Capatina Cristina , Preda Maria , Dumitrascu Anda , Hortopan Dan , Caragheorgheopol Andra , Alexandrescu Daniela , Ciubotaru Vasile , Coculescu Mihail , Poiana Catalina

Background: Craniopharyngioma is a rare, mostly benign tumor of the central nervous system, generally associated with important morbidity.Aim: To study the clinical characteristics and treatment outcome in adult patients.Methods:: Adult patients diagnosed with craniopharyngioma between 1980 and 2012, followed-up in the Pituitary and Neuroendocrine Department of the ‘C.I.Parhon’ National Institute of Endocrinology in Bucha...