Searchable abstracts of presentations at key conferences in endocrinology

ea0052p18 | (1) | UKINETS2017

Circulating Tumour Cells (CTCs) are associated with bone metastases in patients with Neuroendocrine Tumours (NET)

Rizzo Francesca Maria , Childs Alexa , Mandair Dalvinder , Khan Mohid S , Cives Mauro , Ensell Leah , Lowe Helen , Caplin Martyn E , Toumpanakis Christos , Meyer Tim

Background: Bone metastases have been described in up to 15% of patients with NETs and are associated with a worse clinical outcome. Here we investigate the role of CTCs as a marker of bone metastases in a large cohort of patients with gastroenteropancreatic NETs.Methods: To be eligible for the study, patients were required to be ≥ 18 years old, have histologically confirmed midgut or pancreatic NET (pNET) and metastatic disease measurable by RECIS...

ea0089b3 | Basic Science | NANETS2022

Development of a Novel Anti-SSTR Bispecific T-Cell Engager (BiTE)-like Molecule for the Treatment of Neuroendocrine Tumors

Pelle Eleonora , Cives Mauro , Medina Elliot , Mason Charlotte C. , Snedal Sebastian A. , Bustos-Perez Xiomar E. , Tordesillas Leticia , Gomez Fontela Miguel , Marques Rossetti Renata A. , Maiorano Gabriele , Luca Vince , Hwu Patrick , Abate-Daga Daniel , Strosberg Jonathan

Background: Well-differentiated neuroendocrine tumors (NETs) are characterized by the overexpression of somatostatin receptors (SSTRs). To efficiently engage and activate tumor infiltrating lymphocytes against NET cells, we designed a novel bispecific T-cells engager (BiTE) composed of 2 molecules of somatostatin-14 (SST14), the hormone that physiologically binds SSTRs, linked with a single chain variable fragment (scFV)-based anti-CD3.Methods: The optim...