Searchable abstracts of presentations at key conferences in endocrinology

ea0003p209 | Reproduction | BES2002

Cardiovascular risk profiles in women with polycystic ovarian syndrome (PCOS)

Bickerton A , Clark N , Meeking D , Crook M , Shaw K , Cummings M

Introduction: Studies have suggested that PCOS is associated with increased cardiovascular (CVS) risk. The mechanisms that may contribute to increased CVS susceptibility include endothelial dysfunction, vascular inflammation and atherothrombosis.Aim: To compare CVS risk profiles in women with PCOS and healthy age and weight matched controls using novel biochemical and biophysical markers of these pathological processes.Method: Fo...

ea0003p263 | Steroids | BES2002

Growth hormone increases fat mass in patients with simple obesity

Tomlinson J , Crabtree N , Clark P , Holder G , Shackleton C , Stewart P

Patients with obesity are relatively Growth Hormone (GH) deficient. GH has potent effects on adipocyte biology, stimulating lipolysis but also promoting pre-adipocyte proliferation. Conversely, we have shown that cortisol inhibits pre-adipocyte proliferation and enhances differentiation. Furthermore, GH, acting through IGF-1, inhibits 11 beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) which converts the inactive glucocorticoid, cortisone (E) to active cortisol (F) in ad...

ea0005oc10 | Cardiovascular Endocrinology | BES2003

Genomic analysis of congenic rat strains identifies a new candidate gene for human hypertension

McBride M , Carr F , Graham D , Anderson N , Clark J , Lee W , Charchar F , Brosnan M , Dominiczak A

Objective. The aims of our study were to utilise a combination of high fidelity phenotyping, microarray gene expression profiling and conserved synteny mapping between rodent and human genomes to identify genetic determinants underlying human hypertension.Methods. We used the stroke-prone spontaneously hypertensive rat (SHRSP) and a congenic strain (SP.WKYGla2c*) produced by introgressing a quantitative trait locus responsible for blood pressure regulation on rat chromosom...