Searchable abstracts of presentations at key conferences in endocrinology

ea0035oc6.3 | Bone, calcium & vitamin D | ECE2014

Hypoparathyroidism: The burden of illness and impact on patients' personal lives

Clarke Bart , Sanders James , Lagast Hjalmar

Hypoparathyroidism, a rare endocrine disorder of insufficient parathyroid hormone, leads to hypocalcemia and often hyperphosphatemia. The PARADOX study assessed the clinical and personal disease impact from the affected patients’ perspective.Patients ≥18 years and diagnosed ≥6 months ago completed a non-validated, self-reported, web-based survey.Three hundred and seventy-four US adults (mean age, 49 years; women, 8...

ea0073aep84 | Calcium and Bone | ECE2021

Non-nuclear cataracts in hypoparathyroidism are associated with biochemical control of the disease

Zavatta Guido , Tebben Peter , Clarke Bart L.

IntroductionA high calcium-phosphate product is thought to increase the risk of soft tissue calcification in hypoparathyroidism, including cataracts. Based on small case series, cataracts in hypoparathyroidism typically develop in the posterior subcapsular region of the lens. However, the mechanism of cataract formation is still not well understood.Materials and methodsIn a large cohort of 1014 patients with ...

ea0081p561 | Calcium and Bone | ECE2022

Nutritional and clinical manifestations of normocalcemic hyperparathyroidism in women: interim results from a case-control cross-sectional study evaluating dietary calcium intake with three validated questionnaires

Malagrino Matteo , Altieri Paola , Clarke Bart , Pagotto Uberto , Zavatta Guido

Context: Normocalcemic hyperparathyroidism (NHPT) is considered as an earlier or milder phenotype compared to traditional primary hyperparathyroidism (PHPT). To make a correct diagnosis, secondary hyperparathyroidism due to low calcium intake must be excluded. Whether calcium intake might affect presentation of PHPT vs NHPT has never been addressed consistently.Objective: To describe patients with a diagnosis of NHPT or PHPT in relation to their calcium ...

ea0081p50 | Calcium and Bone | ECE2022

Impact of chronic hypoparathyroidism on symptom severity and interference with life as reported by patients treated with recombinant human parathyroid hormone (1-84), rhpth(1-84)

Clarke Bart L. , Hadker Nandini , Athavale Amod , Kolev Irana , Ayodele Olulade

Chronic hypoparathyroidism is a rare mineral homeostasis disorder managed by conventional therapy (oral calcium and active vitamin D), alone or with adjunctive rhPTH(1-84). Chronic hypoparathyroidism is associated with considerable symptom burden, which can interfere with daily living. We report results from a web-based, cross-sectional survey conducted among adults with chronic hypoparathyroidism. The objectives were to quantify the impact on overall life interference of (1) ...

ea0035p160 | Calcium and Vitamin D metabolism | ECE2014

PARADIGHM: a natural history registry for patients with chronic hypoparathyroidism

Bowlin Steven , Sadowski Tara , Vokes Tamara , Bilezikian John , Clarke Bart , Mannstadt Michael , Shoback Dolores , Lagast Hjalmar

Chronic hypoparathyroidism affects ~2.5/10 000 individuals in the European Union and is classified as a rare disorder. There is limited knowledge of the natural history and epidemiology of this disease. Publications frequently represent a single center’s experience and information across the population of patients with hypoparathyroidism is lacking and needed. To fill the gap, a voluntary global hypoparathyroidism patient registry (PARADIGHM) was initiated by NPS Pharmace...

ea0056gp176 | Parathyroid | ECE2018

Symptom burden and HRQoL reported among patients with chronic hypoparathyroidism: impact of treatment with rhPTH (1-84) and with standard therapy

Chen Kristina , Hadker Nandini , Abibova Irana , Hanbury-Brown Lachlan , Vera-Llonch Montserrat , Clarke Bart

Chronic hypoparathyroidism (HypoPT) is a rare disease associated with a variety of symptoms and diminished health-related quality of life (HRQoL). This study aimed to characterise and quantify the symptom burden, HRQoL, and overall disease impact in patients receiving recombinant human parathyroid hormone (rhPTH1-84, Natpar®) for inadequately controlled HypoPT and in symptomatic patients receiving standard therapy (ST; calcium and/or vitamin D supplements). A w...

ea0035oc6.5 | Bone, calcium & vitamin D | ECE2014

The effect of recombinant human parathyroid hormone, rhPTH(1–84), on vitamin D metabolism and phosphate homeostasis: Results from phase III 24-Week REPLACE and phase I clinical studies

Brandi Maria Luisa , Beckers Albert , Vokes Tamara , Mannstadt Michael , Bilezikian John , Clarke Bart , Lagast Hjalmar , Shoback Dolores

PTH promotes conversion of 25-hydroxyvitamin D (25[OH]D) to 1,25-dihydroxyvitamin D (1,25[OH]2D), thus stimulating intestinal calcium and phosphate absorption. Because of low PTH levels in hypoparathyroidism, patients are prescribed calcitriol. Patients are predisposed to hyperphosphatemia owing to loss of PTH-stimulated phosphate excretion by the kidneys. Effects of rhPTH(1–84) on vitamin D metabolism and serum phosphate were studied.In ...

ea0063gp25 | Calcium and Bone 1 | ECE2019

Impact of chronic hypoparathyroidism on health-related quality of life, symptoms, employment, and relationships: findings from a 13-country patient survey

Bollerslev Jens , Bent-Ennakhil Nawal , Chen Kristina , Clarke Bart L , Dahl-Hansen Helen , Germak John , Gibson Katie , Glenister Elizabeth , Judge Davneet , Marelli Claudio , Siggelkow Heide

Significant knowledge gaps exist regarding the humanistic effects of hypoparathyroidism, a rare, debilitating disorder. We report results from a global survey to characterise the burden of hypoparathyroidism from the patient perspective. An anonymous survey was conducted in patients with uncontrolled chronic hypoparathyroidism (as determined by patients’ report of persistent symptoms and/or poorly controlled calcium levels as told by their physician) despite receiving con...

ea0049ep291 | Calcium & Vitamin D metabolism | ECE2017

Chronic hypoparathyroidism disease profile from 492 patients in the PARADIGHM™ natural history global registry

Clarke Bart L , Ing Steven , Khan Aliya , Mannstadt Michael , McDermott Michael , Piccolo Rebecca , Shanik Michael H. , Vokes Tamara J , Germak John

PARADIGHM™ is a global registry (NCT01922440) of patients diagnosed with hypoparathyroidism (HPT) ≥6 months regardless of aetiology and management. Routine medical care data were entered using electronic case report forms; the 36-item Short Form Health Survey was completed by patients. Baseline-recorded data are reported for 492 patients enrolled as of 1 December 2016 from 41 centres. At baseline, 78% were women, mean (S.D.) age was 49 (17)...

ea0041ep129b | Bone & Osteoporosis | ECE2016

Similarities in postsurgical vs nonsurgical patients with hypoparathyroidism: post hoc analysis from recombinant human parathyroid hormone (rhPTH[1-84], parathyroid hormone rDNA) REPLACE study

Brandi Maria Luisa , Bilezikian John P , Clarke Bart L , Fraser William , Krasner Alan , Lagast Hjalmar , Li Benjamin , Mannstadt Michael , Rejnmark Lars , Shoback Dolores M , Vokes Tamara J

Hypoparathyroidism, a rare disorder characterized by absent or low levels of parathyroid hormone (PTH), often results from thyroid surgery. However, nonsurgical etiologies are present in >10% of patients. Data about this group of patients are limited.In this post hoc REPLACE (NCT00732615, EudraCT2008-005063-34) analysis, baseline characteristics and response to 50–100 μg/day rhPTH(1-84) in patients with postsurgical or nonsurgical ...