Searchable abstracts of presentations at key conferences in endocrinology

ea0011p375 | Diabetes, metabolism and cardiovascular | ECE2006

The acute stimulation of nitric oxide synthesis by rosiglitazone in human aortic endothelial cells is independent of the PPAR gamma receptor but is dependant on the fuel sensing enzyme AMPK

Boyle JG , Salt IP , Cleland SJ , Connell JMC

The PROactive study recently demonstrated that pioglitazone, a thiazolidinedione class drug, reduces macrovascular morbidity and mortality in patients with type 2 diabetes. This class of drug has been reported to exert PPAR gamma receptor dependent as well as receptor independent effects, possibly via AMP kinase activation (AMPK) but the precise mode of action resulting in improved cardiovascular outcome remains uncertain.We studied the effects of rosigl...