Searchable abstracts of presentations at key conferences in endocrinology

ea0035p612 | Endocrine tumours and neoplasia | ECE2014

Metabolic and cardiovascular complications in patients with adrenal incidentalomas

Gheorghiu Monica Livia , Voicu Alina , Caragheorgheopol Andra , Coculescu Mihai , Poiana Catalina

Introduction: We evaluated the prevalence of metabolic and cardiovascular complications in a Romanian population with adrenal incidentalomas in comparison with an age-matched control group, evaluated in our clinic.Patients and methods: After excluding patients with overt functioning adrenal tumors, subclinical pheochromocytomas, malignant tumors, myelolipomas, data were retrieved from the files of 190 patients with adrenal incidentalomas ≥1 cm and ...

ea0031p259 | Pituitary | SFEBES2013

Short-term (3 months) compared to long-term response to somatostatin analogues in acromegaly

Gheorghiu Monica Livia , Vintila Madalina , Purice Mariana , Poiana Catalina , Coculescu Mihai

Objective: To evaluate whether serum GH and IGF1 levels achieved after 3 months treatment with somatostatin analogues (SSA) are concordant with the efficacy of SSA after longer treatment with the same dose.Patients and methods: From 71 patients with acromegaly treated with SSA in our clinic, in 38 of them (28 women, 10 men, aged 22–62 years) data on serum GH and IGF1 were available at baseline, after 3 months and at the last evaluation on the same S...

ea0022p455 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Clinical characteristics of incidentally discovered phaeochromocytomas

Gheorghiu Monica Livia , Baciu Ionela , Mangalagiu Mara , Banaru Ana , Poiana Catalina , Badiu Corin , Coculescu Mihai

Introduction: Phaeochromocytomas (PHEO) are tumours of the chromaffin cells and are usually detected due to the typical symptom triad including headache, palpitations and sweating associated with persistent and/or paroxysmal blood hypertension. An increasing proportion of PHEO is incidentally discovered upon abdominal imaging.Objective: To analyse the clinical characteristics of the incidentally discovered phaeochromocytomas.Method...

ea0022p498 | Female reproduction | ECE2010

CAG repeat alleles of the androgen receptor are associated with polycystic ovary syndrome (PCOS) in the Romanian population

Radian Serban , Baculescu Nicoleta , Aflorei Daniela , Gussi Ilinca , Vladoiu Suzana , Ianas Olga , Grigorescu Florin , Coculescu Mihai

Background: Androgen receptor (AR) activity is modulated by the length of CAG-repeat polymorphism in exon 1. Published data suggest association between CAG-repeat alleles and PCOS, but not all studies confirmed this finding.Aim: To test association of AR alleles with PCOS and clinical and biochemical signs of hyperandrogenism.Study design: Case–control association study, approved by the institutional ethical committee, of 137 ...

ea0021p278 | Pituitary | SFEBES2009

Remission rate in microprolactinomas treated with dopamine agonists

Gheorghiu Monica Livia , Trifanescu Raluca , Caragheorgheopol Andra , Hortopan Dan , Dumitrascu Anda , Coculescu Mihai

Introduction: Remission rate in microprolactinomas after treatment with dopamine agonists (DA) is variable, from about 25% in bromocriptine-treated patients to 46% in those treated with cabergoline.Patients: We retrospectively studied the remission rate in 98 patients with prolactinomas ≤1 cm evaluated in 1982–2009 in our department and treated with DA for at least 1 year.Results: Mean age of patients is 26.5±8 year...

ea0016p160 | Clinical cases | ECE2008

Clinical efficacy of intramuscular versus oral testosterone undecanoate in adult men with hypogonadotropic hypogonadism

Gheorghiu Monica Livia , Badiu Corin , Caragheorgheopol Andra , Giurcaneanu Mihaela , Coculescu Mihai

Aim: To evaluate the clinical efficacy of androgen replacement therapy with oral or intramuscular (i.m.) testosterone undecanoate (T.U.) in male patients with central hypogonadism.Patients and methods: We retrospectively evaluated 40 patients with hypogonadotropic hypogonadism: 29 with pituitary tumors or craniopharyn-giomas, 11 with non-tumoral hypogonadism (median age 47 years, range 20–62), before and after androgen replacement therapy, with the ...

ea0014p566 | (1) | ECE2007

Cerebrospinal fluid (CSF)/serum albumin ratio shows no alteration of the blood-brain barrier in patients with pituitary adenomas and high CSF levels of pituitary hormones

Gheorghiu Monica Livia , Purice Mariana , Rusu Catrinel , Galoiu Simona , Tanasescu Ruxandra , Niculescu Dan , Coculescu Mihai

Some patients with pituitary adenomas show high CSF levels and/or high CSF/serum ratio for peptidic pituitary hormones (PR), potentially due to a blood-brain barrier (BBB) damage. We evaluated albumin.CSF/serum ratio (AR) in patients with pituitary adenomas and elevated PR, as an accurate index for a BBB damage.Patients and methods: We evaluated 10 controls (21–79 years, 6M /4 F) before undergoing abdominal or peripheral surgery and 52 patients with...

ea0022p437 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

RET mutation screening in multiple endocrine neoplasia type 2 (MEN2) and medullary thyroid carcinoma patients (MTC) in Romania

Loreta Paun Diana , Radian Serban , Iconaru Laura , Badiu Corin , Grigorie Daniel , Marinescu Ileana , Coculescu Mihai , Dumitrache Constantin

Background: According to current guidelines, RET mutation screening is indicated for MEN2 and familial MTC (FMTC) kindreds, as well as for apparently sporadic MTC patients.Aim: To investigate RET mutations in Romanian MEN2, FMTC and sporadic MTC cases.Patients and methods: RET mutation screening was performed by high-resolution melting analysis followed by direct sequencing of PCR products of exons 10-11 in 7 MEN2A families, 2 FMTC...