Searchable abstracts of presentations at key conferences in endocrinology

ea0020p533 | Paediatric Endocrinology | ECE2009

Prevalence of autoimmune thyroiditis in children with diabetes mellitus

Veloza Andreia , Coelho Catarina , Manita Isabel , Cordeiro Maria , Passos Dolores , Raimundo Luisa , Portugal Jorge

Introduction: Type 1 diabetes mellitus (DM1) is frequently associated with other autoimmune diseases. Among children and adolescents, thyroid disease is the most common autoimmune endocrinopathy. The possibility of occult thyroid disease should be considered at diagnosis and when a patient is assessed at the annual review.Objective: The aim of our study was to determine the prevalence of autoimmune thyroiditis among children and adolescents with type 1 d...

ea0014p424 | (1) | ECE2007

Juvenile osteoporosis in untreated GH-deficient patient – is treatment with GH replacement indicated? A clinical case report

Coelho Catarina , Saraiva Catarina , Manita Isabel , Velosa Andreia , Passos Dolores , Carlos Maria , Raimundo Luisa , Portugal Jorge

Treatment for osteoporosis in children/adolescents is extremely important not only to improve bone quality but also because, if left untreated, could lead to severe and precocious loss of bone mass. Studies in growth hormone (GH) deficient adults, in turn, have shown that treatment with GH produce bone mass gain and improve the occurrence of both bone formation and reabsorption.The authors present the following case report of a 16 year old Caucasian fema...

ea0014p480 | (1) | ECE2007

Bartter syndrome – a case of secondary hyperaldosteronism

Manita Isabel , Veloza Andreia , Coelho Catarina , Saraiva Catarina , Passos Dolores , Cordeiro Maria , Raimundo Luísa , Portugal Jorge

Introduction: Bartter syndrome represents a set of closely related autosomal recessive renal tubular disorders characterised by hypokalemia, hypochloremia, metabolic alkalosis and hyperreninemia with normal blood pressure. The underlying abnormality results in excessive urinary losses of sodium, chloride and potassium. Bartter syndrome is classified into 3 main clinical variants: neonatal Bartter syndrome, classic syndrome and Gitelman syndrome.Case repo...

ea0040oc2 | (1) | ESEBEC2016

mTOR pathway activation in papillary thyroid carcinomas: associations and correlations

Tavares Catarina , Coelho Maria , Melo Miguel , Rocha Adriana , Pestana Ana , Batista Rui , Salgado Catarina , Eloy Catarina , Rios Elisabete , Ferreira Luciana , Sobrinho-Simoes M , Soares Paula

Background: Mammalian target of rapamycin (mTOR) is a downstream effector of the PI3K/AKT pathway. It can be activated by diverse stimuli, such as growth factors, nutrients, energy, stress signals and signaling pathways such as PI3K, MAPK and AMPK, in order to control cell growth, proliferation and survival. The active form of mTOR (pmTOR) may form two distinct complexes: mTORC1 that activates S6K1 and 4EBP1 which are involved in mRNA translation; and mTORC2 that activates PKC...

ea0073ep13 | Adrenal and Cardiovascular Endocrinology | ECE2021

Pheochromocytoma in pregnancy: the need for a multidisciplinary approach

Dias Daniela , Catarina Matos Ana , Inês Sapinho , Coelho Catarina , Borges Augusta , Baleiras Carla , Lima Jorge , Gomes Paulo , Morais Suzette , Cardoso Osvaldo , Lucas Mafalda , Leichsenring Carlos , Pinheiro Nuno

IntroductionPheochromocytoma(PHEO) occurs in pregnancy with an estimated incidence of 0.007%. Its rarity and overlapping presentation with other pregnancy-related hypertensive disorders make the diagnosis really challenging. If left unrecognized, may result in increased maternal and fetal mortality. There are no guidelines on approaching PHEO during pregnancy. This case highlights the difficulties encountered in managing this condition in pregnancy.<...

ea0049ep1449 | Thyroid (non-cancer) | ECE2017

The usefulness of the study of sodium iodide symporter expression in thyroid primary tumors

Tavares Catarina , Coelho Maria Joao , Eloy Catarina , Melo Miguel , da Rocha Adriana Gaspar , Pestana Ana , Batista Rui , Ferreira Luciana Bueno , Rios Elisabete , Cavadas Bruno , Pereira Luisa , Selmi-Ruby Samia , Simoes Manuel Sobrinho , Soares Paula

Thyroid cancer therapy is based on surgery followed by radioiodine treatment of tumor remnants and metastases. The incorporation of radioiodine by cancer cells is mediated by sodium iodide symporter (NIS), normally present in thyroid follicular cellsÂ’ membrane. We studied the expression of NIS in a series of 229 thyroid primary tumors using real time PCR and immunohistochemistry, and searched for possible associations between NIS expression and clinicopathological feature...