Searchable abstracts of presentations at key conferences in endocrinology

ea0019p285 | Reproduction | SFEBES2009

Evidence for discordant granulosa cell proliferation in ovaries of prenatally androgenised sheep: a model for polycystic ovary syndrome

Comim F , Stubbs S , Hardy K , Franks S

Polycystic ovary syndrome (PCOS) is the commonest cause of anovulatory infertility in women. Recent evidence suggests that early folliculogenesis is disordered and may contribute to development of anovulation in PCOS. Early follicle development in PCOS is characterised by increased expression of minichromosome maintenance protein-2 (MCM2), a marker of cell proliferation (Stubbs et al. 2007). Increased recruitment of growing preantral follicles has been reported in the p...