Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1190 | Steroid metabolism + action | ECE2017

Homo-dimerisation of cytochrome P450c17 resolves the conundrum of the dual activities of cytochrome P450c17

Holien Jessica , Parker Michael , Conley Alan , Corbin C Jo , Rodgers Raymond , Martin Lisandra

Reproduction requires the temporal and spacial control of specific and exact signals, delivered by locally regulated hormonal flux. In the case of androgen biosynthesis, cytochrome P450 17α-hydroxylase, 17,20-lyase (P450c17) is the key enzyme. However, P450c17 is a multi-functional P450, so, it synthesizes cortisol in the zona fascicula of the adrenal cortex and also androgen precursors in the adrenal zona reticularis and the gonads. The regulation of this dual activity h...