Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.15.05 | Diabetes and obesity – basic | ECE2015

Stable analogues of the dual agonist dogfish glucagon show better therapeutic potential than exendin-4 in diet induced obese diabetic mice

O'Harte Finbarr P M , Ng Ming T , Conlon J Michael , Flatt Peter R

Recent acute in vivo studies have shown that structural modifications of dogfish glucagon improves peptide stability and these analogues can act as dual agonists at both glucagon and GLP-1 receptors. Here, we compared the effects of chronic (51 days) twice daily administration of [D-Ala2]dogfish glucagon (Pep-N) and [D-Ala2]dogfish glucagon-exendin-4(31–39) construct (Pep-C), exendin-4(1–39) or saline treat...

ea0014s5.1 | Novel bioactive peptides – lessons from animals | ECE2007

Discovery of novel bioactive peptides: the uniquely important contribution of amphibians to mammalian neuropeptidology

Vaudry Hubert , Tostivint Hervé , Lihrmann Isabelle , Chartrel Nicolas , Fournier Alain , Leprince Jérôme , Tonon Marie-Christine , Conlon J. Michael

The concentration of many neuropeptides in the brains of ectothermic vertebrates is several orders of magnitude higher than in the brains of mammals. We have taken advantage of this singular situation to isolate from the brain of the European green frog, Rana esculenta, a number of regulatory peptides that are orthologous to mammalian neuroendocrine peptides. These include α-MSH, γ-MSH, two tachykinins, two GnRH variants, CRH, PACAP, NPY, CGRP, CNP, GRP, and O...