Searchable abstracts of presentations at key conferences in endocrinology

ea0035p683 | Growth hormone IGF axis basic | ECE2014

The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome

Siemienowicz Katarzyna , Boswell Lyndsey , Carr David , Mina Theresia , Connolly Fiona , Rae Mick , Duncan Colin

Exposure of pregnant sheep to increased concentrations of testosterone during midgestation results in a PCOS-like condition in the female offspring that includes increased hepatic IGF1. The aim of this study was to investigate the molecular pathophysiology of this increase. We studied 11-month-old female offspring whose mother had been treated with testosterone propionate (TP: 100 mg) in oil (n=8), or oil control (n=4) twice weekly from day 62 to 102 gestatio...