Searchable abstracts of presentations at key conferences in endocrinology

ea0032p634 | Growth hormome IGF axis – basic | ECE2013

GH therapy: never say never; clinical case

Ghita Irina , Profiri Corina , Constantinescu Georgiana , Novac Roxana , Mogos Voichita

We present the case of a patient diagnosed with panhypopituitarism at an adult age. The tenth child of a poor family, PA consulted the endocrinologist accompanied by his 65 year old mother. PA was 20 years old at the first consultation. He was, however, entrapped in the body of a 12 year old child, being only 139 cm tall and having no signs of puberty onset. He was slightly eunuchoid, with long limbs, due to delayed puberty, with micropenis and lack of androgen dependent hair,...

ea0063p823 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Pheochromocytoma affecting Pregnancy: still searching the needle in the haystack?

Langton Katharina , Constantinescu Georgiana , Richter Susan , Gieldon Laura , Lenders Jacques , Eisenhofer Graeme

Introduction: Pheochromocytoma associated with pregnancy carries a great risk for adverse fetal and maternal outcome, especially when the diagnosis is missed. Symptoms can present in a wide variety regarding intensity and duration, making it difficult for the treating midwife or obstetrician to draw correct conclusions.Clinical Case: We present a case of a 29 years old patient whose third pregnancy was complicated by short, but frequent and intense spell...

ea0032p88 | Bone and Osteoporosis | ECE2013

Lean body mass and leptin, but not fat mass are independent predictors of bone mass in postmenopausal women

Constantinescu Georgiana , Novac Roxana , Gaspar Ioana , Preda Cristina , Vulpoi Carmen , Mogos Voichita , Branisteanu Dumitru D

Body weight is positively correlated to bone mass. While gravity represents a stimulation stress for bone turnover, endocrine function of adipocytes may also influence bone.Objectives: We investigated the relative influence of weight, body composition and leptin upon lumbar bone mass in pre and postmenopausal women.Materials and methods: Cross-sectional study including six groups varying from 8 to 15 pre- / postmenopausal healthy v...

ea0032p168 | Calcium and Vitamin D metabolism | ECE2013

A clinical case of complicated hyperparathyroidismwith diagnosis delay due to vitamin D deficiency

Novac Roxana , Constantinescu Georgiana , Oprea Andreea , Mogos Voichita , Branisteanu Dumitru D

We present the case of a 75-year-old woman with a 10-year history of nephrolithiasis, for which she endured several sessions of extracorporeal shockwave lithotripsy (ESWL). She was directed to the Endocrinology unit for further investigations, due to persistent albeit minor increased values of blood calcium (10.48 mg/dl, normal 8.4–10.2 mg/dl). Here, the clinical supposition of primary hyperparathyroidism was confirmed. The tests revealed a mild hypercalcemia with hypopho...

ea0063p56 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

A difficult diagnosis: pheochromocytoma or methamphetamine abuse?

Constantinescu Georgiana , Leike Steffen , Kunath Carola , Langton Katharina , Gruber Matthias , Peitzsch Mirko , Deinum Jaap , Lenders Jacques , Eisenhofer Graeme

Introduction: Pheochromocytomas represent rare but potential lethal tumors arising from the adrenal medulla. Early recognition and diagnosis represent a challenge due to the non-specific character of signs and symptoms. The classic presentation includes headache, sweating, palpitations and other signs and symptoms of apparent catecholamine excess occurring in paroxysms. Sympathomimetics may result in a similar presentation, potentially complicating the diagnosis.<p class="...

ea0049ep1073 | Pituitary - Clinical | ECE2017

Aggressive macroprolactinoma – exception to the rule

Belceanu Alina Daniela , Constantinescu Georgiana , Crumpei Iulia , Bursuc Anamaria , Rotariu Daniel , Constantinescu Aurora , Ciubotaru Vasile , Preda Cristina , Vulpoi Carmen

Background: Prolactinoma is the most frequent pituitary tumour. However, peculiar aspects may induce difficulties in their evolution and management. Malignant prolactinoma is exceptionally rare and it cannot be diagnosed on histological grounds alone. We report the case of a recurrent, possibly malignant macroprolactinoma.Case report: 46 years old female, addressed for bitemporal hemianopia, without other clinical signs. MRI confirmed a pituitary macroad...

ea0049ep1076 | Pituitary - Clinical | ECE2017

Pituitary adenoma and elevated ACTH: not always corticotrophinoma

Cabac Mariana , Belceanu Alina Daniela , Crumpei Iulia , Tirnovan Mirela , Constantinescu Georgiana , Bursuc Anamaria , Constantinescu Aurora , Mogos Voichita , Vulpoi Carmen

Introduction: Hypothalamic–pituitary–adrenal (HPA) axis activation is the main neuroendocrine response to an environmental challenge. Drug abuse may activate HPA axis by interaction with neuromodulation systems.Case report: 28 year old man, was admitted in the Neurology Department for persistent headache with spinal irradiation. With suspicion of multiple sclerosis, MRI revealed pituitary macroadenoma (14 mm diameter) and subcortical, paraventr...

ea0049ep1209 | Clinical case reports - Thyroid/Others | ECE2017

Autoimmune thyroid disease occurring as a possible late complication after a non-occupational HIV Postexposure Prophylaxis

Crumpei Iulia , Mogos Voichita , Ungureanu Maria-Christina , Bursuc Anamaria , Armasu Ioana , Tirnoveanu Mirela , Adomnicai Valentina , Constantinescu Georgiana , Vulpoi Carmen

Introduction: Nonoccupational postexposure prophylaxis (nPEP) is a three-drug antiretroviral regimen used to decrease the risk for HIV infection after less than 72 h from nonoccupational exposure to body fluids that might contain HIV. The most frequent side effects concern the gastro-intestinal intolerance, renal and hepatic toxicity, with no hormonal imbalance to have been yet reported.Case report: 24 years old male patient, consulted for palpitations, ...

ea0049ep1345 | Thyroid (non-cancer) | ECE2017

Broken heart by thyroid? A rare case of Graves’ disease associated to Takotsubo cardiomiopathy

Constantinescu Georgiana , Plesoianu Carmen , Raileanu Cezara , Ardeleanu Iuliana , Negru Mihaela , Zmau George , Arsenescu-Georgescu Catalina , Vulpoi Carmen

Introduction: Takotsubo disease is a non-ischemic, reversible form of cardiomyopathy, triggered by intense emotional or physical stress. Characterized by normal coronaries and a particular ventricular contraction, it is also known as ‘apical ballooning syndrome’. Thyrotoxicosis, especially Graves’ disease, has been associated with Takotsubo cardiomyopathy.Case report: We report the coexistence of Takotsubo cardiomyopathy in a 37 year old f...

ea0041ep304 | Clinical case reports - Pituitary/Adrenal | ECE2016

Association of two aggressive tumors (prolactinoma and multiple meningioma) – difficult issue, difficult management

Constantinescu Georgiana , Belceanu Alina , Haba Danisia , Constantinescu Aurora , Rotariu Daniel , Bursuc Anamaria , Armasu Ioana , Preda Cristina , Vulpoi Carmen

Introduction: The coexistence of pituitary adenoma and meningiomas is very rare. It is debatable if meningiomas result as a consequence of hormone dependent growth or secondary to radiation.We report a rare case of coexisting brain tumors: a prolactin secreting pituitary adenoma and two meningiomas in a 54-year-old female patient.Case report: Onset at 46 years with bitemporal hemianopsia, without other clinical complaints. MRI conf...