Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp211 | Pituitary Clinical | ECE2018

A systematic review and meta-analysis of endocrine-related adverse events associated with immune checkpoint inhibitors

de Filette Jeroen , Andreescu Corina , Cools Filip , Bravenboer Bert , Velkeniers Brigitte

Background: Monoclonal antibodies targeting CTLA-4 and PD-1/PD-L1 are promising for a wide range of advanced malignacies. These immune checkpoint inhibitors (ICI) provoke endocrine adverse events including hypopituitarism and primary thyroid disease.Methods: PubMed was searched through August 22nd, 2017, for relevant articles on endocrinopathies and ICI, by two reviewers independently (J.d.F. and C.A.). The weighted incidence and odds-ratio were estimate...