Searchable abstracts of presentations at key conferences in endocrinology

ea0081p96 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Increased haematocrit mediates lowering of blood glucose in mice exposed to hypoxia or treated with erythropoetin

Scherer Thomas , Metz Matthaeus , Beghini Marianna , Durr Sabine , Corina Luca Andreea , Kaplanian Mairam , Abu Eid Sameer , Kautzky-Willer Alexandra , Furnsinn Clemens

Introduction: Mountain dwellers show a lower prevalence of diabetes, which among countless other factors could be due to lower partial oxygen pressure at high altitude. The present study was to investigate in an experimental setting, if and how reduced oxygen availability affects blood glucose.Methods: Male obese mice on high fat diet were continuously maintained under a normobaric hypoxic atmosphere (10% oxygen) for three months. To exclude indirect eff...