Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1220 | Clinical case reports - Thyroid/Others | ECE2017

Diagnosis of medullary thyroid carcinoma at early stage

Stancu Cristina , Corneci Cristina , Caragheorgheopol Andra , Stanescu Bogdan , Diana Ilie Mirela , Badiu Corin

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor derived from the thyroid C cells producing calcitonin, ac-counts for 0.6% of all thyroid cancers. It occurs either sporadically or in a hereditary form (RET mutation). MTC can be cured only by complete resection of the thyroid tumor and any loco-regional metastases. Calcitonin (CT) measurement is crucial to the early diagnosis and the follow-up of MTC. If the evaluation of stimulated CT levels is required, a prov...

ea0049ep1395 | Thyroid (non-cancer) | ECE2017

Stimulated calcitonin levels as a predictor of medullary thyroid cancer

Alexandra Gheorghiu Cristina , Corneci Cristina , Jercalau Simona , Dobrescu Ruxandra , Mihai Daniel , Badiu Corin

Abstract: Medullary thyroid cancer (MTC) is a highly aggressive neuroendocrine tumour originating in the thyroid parafollicular cells. Calcitonin measurement and RET gene ascertainment have been used as markers for early diagnosis of MTC. Since pentagastrin is not available, calcium stimulation test helps to preclude ‘gray zone’ values of basal calcitonin, diagnose minimal residual disease and help the early diagnosis of C cell hyperplasia.Aim:...

ea0056p1010 | Endocrine tumours and neoplasia | ECE2018

Thresholds of basal and calcium stimulated calcitonin for diagnosis of medullary thyroid carcinoma

Baetu Mara , Gheorghiu Cristina , Corneci Cristina , Ioachim Dumitru , Caragheorgheopol Andra , Dobrescu Ruxandra , Badiu Corin

Introduction: The current revised medullary thyroid carcinoma (MTC) guidelines don’t specify reference ranges of basal (bCT) or stimulated serum calcitonin (sCT) levels for the diagnosis of MTC. These are important for early diagnosis and correct management.Objective: We aimed to set gender specific thresholds for bCT and sCT for MTC diagnosis.Patients and methods: CT samples during calcium-stimulation test (2...

ea0090p506 | Thyroid | ECE2023

A Rare Association of Thyroid Medullary Carcinoma with Paraneoplastic Cushing Syndrome: Effects of Multidisciplinary Approach

Alexandra Olariu Cristina , Marin Alexandra , Corneci Cristina , Badiu Corin

Introduction: Medullary thyroid cancer (MTC) is a neuroendocrine tumor of the parafollicular or C cells of the thyroid gland. While thyroid cancer is increasingly common worldwide, MTC still has a low incidence. We present a case of a seventy-one-years-old woman who presented in our unit after an axillary adenopathy biopsy which tested sparsely positive for KeratinPan, CK7, CEA, TTF1, Chromogranin, Snaptophysin and calcitonin, focal positive for EMA, PAX8, Ki67 30%. Also multi...

ea0063p1062 | Pituitary and Neuroendocrinology 3 | ECE2019

Osteitis fibrosa cystica of the skull in a patient with primary hyperparathyroidism

Biban Georgiana Bianca , Baleanu Maria , Baculescu Nicoleta , Smarandache Romeo Marian , Corneci Cristina , Hortopan Dan , Poiana Catalina

Background: Overt parathyroid bone disease is a rare entity. We present a case of primary hyperparathyroidism (PHPT) and osteitis fibrosa cystica with involvement of multiple facial bones and neurocranium. Although the initial differential diagnosis was between acromegaly and bone malignancy, endocrine assessment demonstrated PHPT, with favorable outcome after parathyroidectomy.Case report: A 59-year-old woman referred to our clinic with painful swelling...

ea0032p545 | Endocrine tumours and neoplasia | ECE2013

The metabolic complications in adrenal tumors: a retrospective study in 56 patients

Poiana Catalina , Carsote Mara , Hortopan Dan , Corneci Cristina , Gruia Adriana , Trifanescu Raluca , Stanescu Bogdan , Paun Diana

Introduction: The metabolic complications in adrenal tumors, regardless secretor or not, are a common finding, thus representing a supplementary warning in these patients related to the non-endocrine therapy as anti-hypertensives, or hypolipemiants drugs, etc.Aim: We analyze the frequency of metabolic complications in primitive adrenal tumors.Materials and methods: This is a retrospective study in patients diagnosed with adrenal tu...

ea0073aep672 | Thyroid | ECE2021

Side-effects of calcitonin stimulation tests with calcium gluconate

Baetu Mara , Olariu Cristina , Nitu Ileana , Moldoveanu Gabriel , Corneci Cristina , Badiu Corin

IntroductionOver time, different substances and protocols have been used and tested for stimulating calcitonin (CT). Some of them proved to be useful in diagnosing medullary thyroid carcinoma (MTC). However, these are associated with side-effects, with various duration, intensity and severity.ObjectiveTo report the side-effects observed during CT stimulation test with calcium (Ca) gluconate.<p class="abst...

ea0081ep714 | Pituitary and Neuroendocrinology | ECE2022

Block and replacement therapy of a patient with Cushing’s disease and aggressive complications: a case report

Tănasie Denisa-Isabella , Simona Andreea Găloiu , Caragheorgheopol Andra , Corneci Cristina , Baloseanu Nicoleta , Poiana Catalina

Introduction: We describe a patient with Cushing’s disease caused by a pituitary macroadenoma treated by double transsphenoidal surgery, stereotactic radiosurgery and steroidogenesis inhibitors and also the challenging management of a patient with multiple comorbidities, including chronic leg ulcers, which are related to increased morbidity and health costs.Case report: In October 2019, a 67-year-old patient presented with intense headache, left tem...

ea0081p743 | Thyroid | ECE2022

Concomitant Graves′ disease with COVID-19 infection

Trifanescu Raluca , Toma Iustin-Daniel , - Alexandra Mohora Maria , Cristina Corneci Marioara , Nitu Ileana , Baloseanu Nicoleta , Vladoiu Suzana , Schipor Sorina , Dumitrascu Anda , Poiana Catalina

Background: Subacute thyroiditis, autoimmune thyroiditis and an atypical form of thyroiditis due to primary injury of the thyroid gland by SARS Cov2 itself are complications of COVID-19. Angiotensin-converting enzyme 2 is also expressed in the thyroid gland. On the other hand, both untreated thyrotoxicosis and COVID-19 affects heart, generating cardiac complications.Case report: A 36-year-old woman resident in an iodine sufficient area, heavy smoker, pre...

ea0063p799 | Thyroid 2 | ECE2019

Cut-off values for basal and calcium stimulated calcitonin for the diagnosis of precocious medullary thyroid carcinoma

Băetu Mara , Olariu Cristina Alexandra , Stancu Cristina , Dobrescu Ruxandra , Moldoveanu Gabriel , Corneci Cristina , Caragheorgheopol Andra , Ioachim Dumitru , Badiu Corin

Introduction: Thresholds of basal (bCT) or stimulated serum calcitonin (sCT) levels for the diagnosis of medullary thyroid carcinoma (MTC) aren’t specified in current revised MTC guidelines.Objective: We aim to setfemale (F) specific thresholds for bCT and sCT for MTC diagnosis.Methods: CT samples were measured during calcium-stimulation test (25 mg/kg BW adapted to ideal body mass index) before and at 2, 5 and 10 minutes afte...