Searchable abstracts of presentations at key conferences in endocrinology

ea0035p702 | Male reproduction | ECE2014

Effect of 17β-estradiol on germ cell apoptosis by modulating the expression of SCF/c-kit, FasL/FasR and regucalcin

Correia Sara , Alves Mario R , Martins Ana D , Cavaco Jose E , Oliveira Pedro F , Socorro Silvia

In the last years estrogens have emerged as important regulators in male reproductive function. Spermatogenesis depends on the tight control of germ cell apoptosis and several studies indicated estrogens as playing a role in this process. The stem cell factor (SCF), a membrane-bound cytokine, and its receptor (c-kit), and the Fas ligand (FasL)/Fas receptor (FasR) system are powerful mechanisms controlling germ cell proliferation and apoptosis through the direct membrane commun...

ea0070ep308 | Pituitary and Neuroendocrinology | ECE2020

Insipidus diabetes and vaginal ulcers... evidence for the diagnosis of langerhans cell hypophysitis

Correia Sara , Melo Gustavo , Alves Helena , Almeida Lucia , João Oliveira Maria , Ramalho Diogo

Introduction: Langerhans Cell Histiocytosis (HCL) is a rare granulomatous disease, unknown etiology, with a wide clinical spectrum. The pituitary is affected in 25% of cases, with diabetes insipidus being the earliest and most frequent feature. Although it is more common in pediatric age, it can also be developed by adults.Clinical case: A 39-year-old, caucasian, woman presents with polydipsia with 5L/day of water and an appetite for cold drinks, polyuri...

ea0073pep14.1 | Presented ePosters 14: COVID-19 | ECE2021

Is initial hypocalcemia related to poorer outcomes in COVID-19 patients?

Alves Helena , Ferreira Marta Almeida , Almeida Lucia , Correia Sara , Ramalho Diogo , João Oliveira Maria

IntroductionAlthough most patients with COVID-19 have mild symptoms, some develop severe manifestations of the disease, leading to hospitalization and death. Previous studies reported that calcium played a central role in viral infections and replicative mechanisms of SARS-CoV. Hypocalcemia is a common finding among these patients. The aim of this study was to investigate the prevalence of hypocalcemia in a population of COVID-19 patients and to evaluate...

ea0073aep48 | Adrenal and Cardiovascular Endocrinology | ECE2021

Lipid paradox in acute myocardial infarction

Correia Sara , Ramalho Diogo , Almeida Lucia , Alves Helena , Melo Gustavo , Maria João Oliveira

IntroductionSome studies have shown low-density lipoprotein cholesterol (LDL) and triglyceride (TG) levels were significantly lower in high-Killip (III + IV) patients compared with low-Killip (I + II) patients and in those who died after acute myocardial infarction (AMI) compared with those who survived beyond 30 days, which they called lipid paradox. Elevated levels of LDL and triglycerides are important risk factors for cardiovascular disease, ...

ea0073aep168 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Use of the thrombolysis in myocardial infarction risk score for heart failure in diabetes in a type 2 diabetes mellitus outpatient population

Ramalho Diogo , Correia Sara , Almeida Lucia , Alves Helena , Melo Gustavo , Maria João Oliveira

BackgroundType 2 Diabetes Mellitus (T2DM) and Heart Failure (HF) are two directly related diseases associated with considerable morbimortality. The prevalence of HF in T2DM populations is up to 20%, 4 times higher than the general population. Additionally, health-related quality of life, hospitalizations for HF (HHF) and mortality risk are more common when both are present. Hence, HHF risk assessment in T2DM patients may lead to prompt preventive interve...

ea0070ep176 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Diabetic ketoacidosis and continuous glucose monitoring – a case report

Ramalho Diogo , Rocha Gustavo , Alves Helena , Correia Sara , Almeida Lúcia , João Oliveira Maria

Introduction: Diabetic ketoacidosis (DKA) is characterized by the triad – ketonemia, metabolic acidosis and hyperglycemia. It is typically associated with type 1 Diabetes Mellitus (T1D) and the most common culprits are infections and poor therapeutic compliance.Clinical Case DescriptionThe present case deals with a 25–year–old female patient, with T1D diagnosed in 2008, without microvascular or macrovascular compl...

ea0070ep477 | Thyroid | ECE2020

Thyrotoxicosis and Tuberculosis (TB) related cervical lymphadenopathies: A case report

Almeida Lucia , Sousa Ana , Melo Gustavo , Ramalho Diogo , Correia Sara , Alves Helena , João Oliveira Maria

Introduction: Grave´s disease (GD) is the most prevalent cause of hyperthyroidism, leading to inflammation of the thyroid gland and sometimes to an enlargement of the nearest lymph nodes caused by that same inflammatory process. Peripheral lymphadenopathy of doubtful cause presents a diagnostic dilemma. There are many potential causes: biopsy is sometimes the best way to reach a definitive diagnosis. Tuberculous adenitis is usually regional and mainly affects nodes of the...

ea0073ep209 | Thyroid | ECE2021

Differentiated thyroid carcinoma with metastatic presentation

Almeida Lucia , Almeida Ferreira Marta , Sousa Ana , Alves Helena , Ramalho Diogo , Correia Sara , Maria João Oliveira

IntroductionFollicular thyroid carcinoma (FTC) has metastasis in 10-15%; papillary thyroid carcinoma (PTC) rarely metastasizes. Bone metastasis are rare and can cause pain, fractures and spinal cord compression.Case-172 year-old male referred to the hospital with lower back pain. Imaging examination revealed lytic lumbar lesions. Thoracic-abdominal-pelvic-CT showed trachea compression by a multinodular right ...

ea0084ps2-06-55 | Hypothyroidism Treatment | ETA2022

Free T3 levels and clinical status of patients with levothyroxine-compensated primary hypothyroidism: can we do better?

Ramalho Diogo , Almeida Lucia , Ferreira Marta , Correia Sara , Alves Helena , Carmona Henrique , Rocha Gustavo , Joao Oliveira Maria

Objectives: To evaluate the relationship between free T3 (FT3) levels with symptoms suggestive of thyroid dysfunction, and quality of life (QoL) outcomes, in patients with compensated primary hypothyroidism (PH).Methods: Cross-sectional study encompassing Portuguese levothyroxine(LT4)-treated patients for PH who presented Thyroid-stimulating hormone (TSH) and free T4 (FT4) within the normal range. Pregnant women, patients with central hypothyroidism and/...

ea0070aep652 | Pituitary and Neuroendocrinology | ECE2020

Acrodat – a useful tool to manage acromegaly patients

Alves Helena , Almeida Ferreira Marta , Tavares Patrícia , Ramalho Diogo , Machado Catarina , Almeida Lucia , Correia Sara , João Oliveira Maria

Introduction: Acromegaly is a rare condition associated with metabolic abnormalities, risk of cardiovascular complications and increased mortality. Even when biochemical control is achieved, following surgery or medical treatment, patients still complain about disease-related symptoms.Material and Methods: Retrospective study of acromegaly patients, followed in an Endocrine outpatient clinic. Clinical and biochemical data was recorded. ACRODAT was used t...