Searchable abstracts of presentations at key conferences in endocrinology

ea0037s3.3 | Non-classical causes of hypopituitarism (<emphasis role="italic">Endorsed by Endocrine Connections</emphasis>) | ECE2015

Drug induced hypopituitarism

Corsello Salvatore Maria

Pituitary dysfunctions, reported as ‘hypopituitarism’ or ‘hypophysitis’, are relatively common side-effects induced by monoclonal antibodies (mAbs) inhibiting specific immune checkpoints. In particular, hypophysitis represents a distinctive side effect of CTLA4-blocking antibodies and is a new form of autoimmune pituitary disease.In initial trials, the incidence of hypophysitis induced by anti-CTLA4-mAbs (ipilimumab and tremelimumab) ...

ea0081ep152 | Calcium and Bone | ECE2022

Teriparatide for hypoparathyroidism after bariatric surgery

Maggio Ettore , Morgante Cesare , Ramunno Vittoria , Corsello Andrea , Cera Gianluca , Pontecorvi Alfredo , Corsello Salvatore Maria

Background: Hypoparathyroidism is an endocrine disorder characterized by hypocalcemia due to low levels of parathyroid hormone (PTH). Activated vitamin D (calcitriol) and calcium supplementation may be difficult in patients with malabsorption, as calcium requires an acid environment to dissolve. In this setting, subcutaneous administration of PTH analogues may be effective in reducing the dosage of oral calcium and vitamin D supplementation.Case report: ...

ea0063p434 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

A severe ACTH-dependent Cushing syndrome associated to a possible concomitant primary adrenal-dependent hypercortisolism: a challenging case

Paragliola Rosa Maria , Corsello Andrea , Cese Francesca Delle , Papi Giampaolo , Pontecorvi Alfredo , Corsello Salvatore Maria

Background: Cushing syndrome (CS) represents a challenging disease. The major difficulty is to distinguish between the two main etiologies of ACTH-dependent hypercortisolism. However, in rare cases, the concomitant presence of both an ACTH-dependent and a primary adrenal disease should be considered.Case report: We evaluated a 67-year-old woman for a severe ACTH-dependent CS (midnight serum cortisol 332 ng/ml; urinary free cortisol [UFC] 3000 mcg/day; co...

ea0049ep1426 | Thyroid (non-cancer) | ECE2017

A new strategy to estimate levothyroxine requirement after total thyroidectomy and radioiodine remnant ablation for ‘intermediate’ and ‘high’ risk differentiated thyroid cancer

Paragliola Rosa Maria , De Rosa Annapina , Di Donna Vincenzo , Papi Giampaolo , Pontecorvi Alfredo , Corsello Salvatore Maria

Introduction: The approach for initial thyroid hormone suppression in patients who undergo surgery for differentiated thyroid cancer (DTC), is based upon the risk of disease recurrence. In particular, recent American Thyroid Association guidelines suggest to maintain TSH levels between 0.1 and 0.5 mU/l and less than 0.1 mU/l for patients with ‘intermediate’ and ‘high’ risk respectively. The aim of the study is to identify the major predictive factors of LT4...

ea0049ep1341 | Thyroid (non-cancer) | ECE2017

Is Levothyroxine requirement the same for tablet and soft gel formulation in postsurgical hypothyroidism?

Di Donna Vincenzo , Paragliola Rosa Maria , De Waure Chiara , De Rosa Annapina , Papi Giampaolo , Pontecorvi Alfredo , Corsello Salvatore Maria

Background: In a previous publication we identified the major predictive factors of levothyroxine (LT4) requirement and proposed an efficient nomogram to calculate LT4 substitutive starting dose after total thyroidectomy for benign disease. The aim of this study was to assess whether the LT4 requirement differs between the tablet and the soft gel capsules formulations.Methods: One hundred and three consecutive patients su...

ea0041gp238 | Thyroid Cancer (1) | ECE2016

Correlation between basal and stimulated thyroglobulin in differentiated thyroid carcinoma of intermediate and high risk

Senes Paola , De Rosa Annapina , Paragliola Rosa Maria , Papi Giampaolo , Locantore Pietro , Pontecorvi Alfredo , Corsello Salvatore Maria

Thyroglobulin (Tg) is a highly sensitive tumor marker of differentiated thyroid cancer (DTC). To optimize the sensitivity, guidelines recommend Tg measurement after stimulation with recombinant TSH (rh-TSH) 6–12 months after radio remnant ablation (RRA). Based on recent evidence in Literature, it is possible to avoid the measurement of Tg after stimulation with rh-TSH (S-Tg) in presence of undetectable values of basal Tg (B-Tg) if high functional sensitivity (0.1 ng/ml) m...

ea0035p1140 | Thyroid Cancer | ECE2014

Thyroglobulin before radio remnant ablation during levothyroxine withdrawal can be considered an accurate parameter of remission of differentiated thyroid cancer

Paragliola Rosa Maria , De Rosa Annapina , Di Donna Vincenzo , Locantore Pietro , Senes Paola , Prete Alessandro , Pontecorvi Alfredo , Corsello Salvatore Maria

Introduction: Differentiated thyroid cancer (DTC) is the most frequent endocrine cancer. After surgery followed, if any, by 131I radio remnant ablation (RRA), follow-up monitoring consists of neck ultrasonography (US) and measurements of thyroglobulin (Tg) levels and anti-Tg antibodies (Ac-Tg) both on levothyroxine (L-T4) therapy and after recombinant TSH (rTSH). The aim of our study is to define a cut-off of Tg before RRA (RRA-Tg) during <...

ea0032p1049 | Thyroid (non-cancer) | ECE2013

Subacute thyroiditis: unusual presentation and diagnostic troubles

Paragliola Rosa Maria , Ricciato Maria Pia , Di Donna Vincenzo , Castellino Laura , Lovicu Rosa Maria , Pontecorvi Alfredo , Corsello Salvatore Maria

A 73 years old man came to our observation for severe dysphagia and loss of weight (10 kg in 1 month). About 30 years before he had myocardial infarction and he underwent coronary artery bypass graft. One week before the first medical evaluation, patient suspended all drugs per os because he could not swallow pills and food. Thyroid function test revealed a severe hyperthyroidism (FT3 11.9 pg/ml; FT4 40 pg/ml; TSH <0.01 μU/ml). Anti-TSH ...

ea0020p516 | Paediatric Endocrinology | ECE2009

Short stature in pediatric Cushing's syndrome: effectiveness of hypercortisolism cure

Paragliola Rosa Maria , Lovicu Rosa Maria , Ingraudo Francesca , Ianni Francesca , Locantore Pietro , Rota Carlo Antonio , Pontecorvi Alfredo , Corsello Salvatore Maria

Cushing’s disease (CD) is the most common cause of endogenous Cushing’s syndrome in children and adolescents and represents a rare cause of short stature. A 14-year-old boy came to our attention for progressive weight gain and short stature. Birth length and weight were normal; clinical history was negative for use of glucocorticoids. At examination, height was 140 cm (3th centile), weight was 37.7 kg (10th centile). Tanner stage was: G2, PH 3, testis 3 ml. Hypothyro...

ea0016p150 | Clinical cases | ECE2008

Subclinical Cushing's syndrome (CS): role of 131I-iodomethylnorcholesterol scintigraphy in predicting the evolution of the disease

Paragliola Rosa Maria , Locantore Pietro , Ricciato Maria Pia , Rufini Vittoria , Perotti Germano , Rota Carlo Antonio , Pontecorvi Alfredo , Corsello Salvatore Maria

Subclinical CS, mild hypercortisolism without overt clinical manifestations, is the most frequent (5–8%) hormonal abnormality detected in patients with secreting adrenal incidentalomas.Unclear clinical features and mild hypercortisolism make the diagnosis problematic, although laboratory criteria have recently been reviewed. In these cases, scintiscan is a central tool to define the adrenal functional activity.A 60-year-old ma...