Searchable abstracts of presentations at key conferences in endocrinology

ea0020oc1.1 | Endocrine Tumours | ECE2009

Optimizing time of prophylactic surgery in ret gene carriers on the basis of serum calcitonin

Elisei Rossella , Romei Cristina , Bottici Valeria , Cosci Barbara , Renzini Guilia , Molinaro Eleonora , Agate Laura , Pinchera Aldo

Multiple endocrine neoplasia type 2 (MEN 2) is characterized by the presence of medullary thyroid cancer (MTC) and other benign pathologies. RET mutations are responsible of this disease and their screening is a very sensitive tool for the identification of gene carriers (GC).Aim of this study was to verify the relevance of the basal and pentagastrin (Pg) stimulated serum calcitonin (CT) in the decision to perform TT in GC. We reviewed data of 65 GC foun...

ea0014p362 | (1) | ECE2007

Prognostic value of polymorphisms and somatic RET proto-oncogene mutations in sporadic medullary thyroid carcinoma (MTC)

Cosci Barbara , Romei Cristina , Piampiani Pamela , Sculli Mariangela , Miccoli Paolo , Ugolini Clara , Minuto Michele , Pinchera Aldo , Elisei Rossella

Germline point mutations of the RET proto-oncogene are causative of hereditary MTC. Somatic mutations are described in 40% of sporadic MTCs. Although a relationship between somatic mutations and bad prognosis has been described, data are controversial.No date on the prognostic value of RET polymorphisms are available.Aim of the work was to verify if the presence of a somatic RET mutation and or a polymorphisms can influence the prognosis of MTC. This stu...

ea0014oc1.2 | Thyroid clinical | ECE2007

Expression gene profile may be useful for the diagnosis of thyroid malignancies

Piampiani Pamela , Romei Cristina , Cosci Barbara , Vivaldi Agnese , Ciampi Raffaele , Viola David , Bottici Valeria , Giannini Riccardo , Basolo Fulvio , Pinchera Aldo , Elisei Rossella

Although 20% of follicular neoplasms are papillary thyroid carcinoma (PTC), their cytological diagnosis is not diagnostic. A different profile of gene expression between malignant and benign thyroid tumors has been reported. Aim of this study was to identify a gene expression profile to be used in distinguishing malignant from benign thyroid neoplasms. By real-time RT-PCR we analyzed mRNA expression of 6 thyroid differentiation genes (TTF-1, PAX8, TPO, TSHr, NIS and Tg) and 5 ...

ea0014p365 | (1) | ECE2007

Usefulness of calcitonin (CT) measurement in wash-out fluid from fine needle aspiration biopsy in thyroid nodules of patients with dectectable serum CT

Renzini Giulia , Rago Teresa , Passannanti Paolo , Viola David , Cosci Barbara , Molinaro Eleonora , Grasso Lucia , Lucchetti Fabiana , Vitti Paolo , Pinchera Aldo , Elisei Rossella

Up to now there isn’t any study to validate the CT measurement in wash-out-fluid from FNAB in the diagnosis of medullary thyroid cancer (MTC). To demonstrate the usefulness of CT measurement in wash-out fluid from FNAB in thyroid nodules, we have retrospectively analyzed 25 cases with detectable serum CT in which CT measurement in wash-out-fluid from FNAB, citology and histological examination were available. In 7 cases CT level was <10 pg/ml: cytology was negative in...