Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep705 | Pituitary and Neuroendocrinology | ECE2022

When we count Ki67 in a gonadotropinoma- matters- case report

Costache Outas Mariana

We report the case of a 49 y.o male with an incidental sphenoidal-sellar tumour discovered during a cerebral CT scan during the workup of a medium to severe SARS COV 2 infection. The cerebral MRI describes an invasive tumour located in the sellar region and sphenoidal sinus – extended around the right optic nerve and into both cavernous sinuses. An emergency biopsy from the sphenoidal extension of the tumour revealed a neuroendocrine tumour. The reported diagnostic was ol...

ea0082wb3 | Workshop B: Disorders of growth and development | SFEEU2022

Giant prolactinoma in a prepubertal girl- challenges in the management

Costache Outas Mariana

We report a case of a peripubertal 11 yr old girl with a diagnosis of macroprolactinoma. She was diagnosed 1,5 years before her presentation in our clinic in the context of headache. At the diagnostic, the MRI described a moderate enhancing homogenous mass- of 27/16/14 mm -centred on the diaphragm sellae –extended laterally in the right cavernous sinus in contact with the left optic nerve, anterior in the posterior segment of the olfactory sulcus and inferior to the Meck...

ea0086p192 | Bone and Calcium | SFEBES2022

An initial disturbing finding in the follow-up of medullary thyroid carcinoma after surgery- in the Vth laterocervical compartment may represent a positive course of the disease. Case Report

Costache -Outas Mariana

A 60-year lady with a history of thyroidectomy for medullary thyroid presented for her regular follow-up - first presentation in our clinic in Nov 2020 (previous visits to another endocrinology clinic).History: 2005: uretheroplasty for left uretheral hypoplasia January 2017: thyroid ultrasound: a unique left lobe thyroid nodule (1 cm)- basal calcitonin x3 UNL (nr <11.5) and 94 pg/ml calcium stimulated CTN; RET gene - negative for mutations in exons 8...

ea0065p424 | Thyroid | SFEBES2019

Clustering of papillary thyroid carcinoma, familial hypocalciuric hypercalcemia and parathyroid adenoma in members of the same family–Case report

Costache-Outas Mariana

We report a case of familial clustering of familial hypocalciuric hypercalcemia (FHH) associated with and papillary thyroid carcinoma (PTC). The first presentation in our clinic of one of the patients, female patient, was for severe hypercalcemia. The diagnostic workout for hypercalcemia revealed primary hyperparathyroidism (PHPT) due to a left inferior parathyroid adenoma and undergo surgery. The pathologic report described closely packed chief cells arranged in uniform sheet...

ea0070ep405 | Reproductive and Developmental Endocrinology | ECE2020

The occurrence of the hypogonadotropic hypogonadism as a prediagnostic finding for HIV Infection in a patient with klinefelter under testosterone replacement therapy

Costache Outas Mariana

Background: Hypogonadism is common among human immunodeficiency virus (HIV)-infected men. The actual prevalence remains poorly defined and ranges from less than 10% to over 50% in different studies. Secondary hypogonadism is the most common cause of hypogonadism among HIV-infected men. In hypogonadal HIV-infected men, naive of highly active antiretroviral therapy (HAART), around 75% have secondary hypogonadism due to the suppression of gonadotropins by the active inflammation ...

ea0094p103 | Neuroendocrinology and Pituitary | SFEBES2023

ACTH as a tumour marker in Cushing Disease following surgery

Costache Outas Mariana

Silent corticotroph adenomas are a distinctive subgroup of nonfunctioning pituitary tumours without biochemical or clinical evidence of Cushing’s disease. They are diagnosed after surgery by positive immunostaining for ACTH. They are usually macroadenomas with more aggressive behaviour. On rare occasions, they transform into active Cushing’s disease, with elevated serum ACTH levels. I report a case of a 44 years old lady I first examined in the postoperative neurosur...

ea00100we4.2 | Workshop E: Disorders of the gonads | SFEEU2024

Long-term management of macroprolactinoma on high dose cabergoline with a partial response. two case reports

Costache Outas Mariana

Case 1: A 33-year-old male patient with seven years of erectile dysfunction and aspermia presented for a fertility opinion. He had a diagnostic of macroprolactinoma a year ago when Cabergoline was started with a gradual increase of the dose. Upon his initial evaluation in our clinic, on 2 mg Cabergoline weekly, his serum PRL level was × 10 UNL, decreased 70% from the diagnostic, and the tumour shrinkage was 60% from the diagnostic. A gradual increase of the Cabergoline up...

ea0049ep817 | Paediatric endocrinology | ECE2017

P3NP has high-normal values in GHD children and correlates negatively with IGF1

Costache Outas Mariana , Procopiuc Camelia , Caragheorgheopol Andra , Fica Simona

Aim: Procollagen type III N-terminal peptide (P3NP) occurs during type III collagen synthesis. Previous studies about the GH misuse in athletes proved the P3NP as a growth hormone (GH) responsive biomarker. We evaluate the P3NP levels and correlate with IGF1 depending on GH status.Subjects and Methods: We determined P3NP levels in 81 prepubertal children (35 girls) with a mean age of 6.2 y.o [3.37–9.95]. The group consists of 37 subjects with normal...

ea0056p78 | Adrenal medulla | ECE2018

When the large tumor is not the first intention for removal-concomitant discovery of left adrenal pheochromocytoma and a possible retroperitoneal plexiform neurofibroma in a case of familial neurofibromatosis type 1- case report

Costache Outas Mariana , Valcu Alice , Lamasz Andru , Giulea Cosmin

Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disorder characterized by the development of multiple benign tumors of the nerves and the skin (neurofibromas) and areas of abnormal increased and decreased coloration of the skin. Pheochromocytoma develops in 0.1–5.7% of NF1 patients and plexiform neurofibroma in 30% of NF1 patients. We present a case of a 38-year-old female, without relevant personal, with a familial phenotype suggestive for NF1, evaluated for ...

ea0044p58 | Bone and Calcium | SFEBES2016

Procollagen N-terminal propeptide in children

Costache-Outas Mariana , Procopiuc Camelia , Dumitrescu Cristina , Caragheorgheopol Andra , Costache Cosmina Raluca , Fica Simona

Aim: Somatic growth results from the generation of new support and connective tissue. Since collagen is the major protein constituent of connective tissue, its synthesis must be a prerequisite for the normal growth. The aim of the study was to determine age-related reference intervals for P3NP, a collagen – formation marker in a group of normal height prepubertal children and to compare to IGF1 levels.Subjects: Forty-three prepubertal children, male...