Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep848 | Pituitary and Neuroendocrinology | ECE2023

Opposite tumoral and hormonal responses to low-dose pasireotide in Cushing’s Disease

Serban Andreea , Zampetti Benedetta , Saladino Andrea , Chiodini Iacopo , Cozzi Renato

Pasireotide (Pas) is a multireceptor-targeted somatostatin analogue approved for the treatment of patients with Cushing’s Disease (CD) who fail or are poor candidates to surgery. Pas markedly improves signs and symptoms of the disease, reduces urinary free cortisol (UFC) up to its normalization in 55% of patients and pituitary tumour size in up to 100%. Here we present a patient with severe recurrent CD treated with Pas and showing opposite results between hormonal levels...

ea0016p416 | Neuroendocrinology | ECE2008

Perioperative steroid treatment is not routinely required in endoscopic transphenoidal surgery for clinically non functioning pituitary adenomas (NFPA)

Cozzi Renato , Lasio Giovanni , Felisati Giovanni , Attanasio Roberto

Steroids are still widely prescribed in pituitary trans-sphenoidal surgery (TSA). Pituitary-adrenal/thyroid/gonadal functions were prospectively evaluated in 72 consecutive NFPA pts (20–87 years, 37 M) before and after endoscopic-TSA (E-TSA) (63 at first operation, 9 at re-operation). All had macroadenoma with suprasellar extension: impinging optic chiasma in 28, extending into cavernous sinus (CS) in 23, giant in 12. Hydrocortisone was infused peri-operatively only in pt...

ea0081p171 | Pituitary and Neuroendocrinology | ECE2022

Efficacy of pasireotide LAR for acromegaly: a long-term real-world monocentric study

Zampetti Benedetta , Isabella Carioni Emanuela , Dalino Ciaramella Paolo , Grossrubatscher Erika , Dallabonzana Daniela , Attanasio Roberto , Cozzi Renato

Patients: Nineteen acromegalic patients (8 females, 21-69 years-old, with macroadenoma, microadenoma or no evidence of pituitary tumor in 15, 2, 2, respectively) resistant to first generation somatostatin analogs (FG-SA) at high doses and/or intolerant to pegvisomant were switched to pasireotide LAR (PasLAR). Eleven had persistent disease after neurosurgery and two had also undergone radiosurgery (12 and 24 months before starting PasLAR). Six complained of acromegalic headache...

ea0070aep1065 | Hot topics (including COVID-19) | ECE2020

Efficacy and safety of long-acting pasireotide in acromegalic patients in the real life: The reappraisal of the first-dose follow-up visit

Urbani Claudio , Dassie Francesca , Zampetti Benedetta , Maria Di Certo Agostino , Cozzi Renato , Maffei Pietro , Bogazzi Fausto

Background: Pasireotide is a multi-ligand somatostatin analogue licensed in a long-acting release formulation (PAS-LAR) for the treatment of acromegaly. The real-life reports with PAS-LAR are still scanty.Objectives: To assess the efficacy and safety of PAS-LAR in patients with acromegaly.Patients and methods: Prospective observational multi-centre study enrolling acromegalics evaluated before (baseline) and 1, 6, 12, 24, and 36 mo...

ea0081ep120 | Adrenal and Cardiovascular Endocrinology | ECE2022

COVID-19 pandemic and alternative options to classical pathways: real life experience

Zampetti Benedetta , Pauna Iuliana , Andreani Sara , Carioni Emanuela Isabella , Dallabonzana Daniela , Attanasio Roberto , Boniardi Marco , Cozzi Renato

COVID-19 pandemic obliged physicians to find out alternative options to classical pathways, to lower viral spread and related dangers as well as to cope with redeployment of personnel and resources. We describe here two cases in whom surgery for adrenal Cushing’s syndrome (CS) and pheochromocytoma (PHEO) was deferred due to the unavailability of surgical facilities.Case no 1: A 69-yo woman was evaluated for CS. Type 2 diabetes mellitus was diagnosed...

ea0022p638 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Effects on glucose metabolism of high-dose octreotide LAR in patients with acromegaly inadequately controlled by conventional somatostatin analog therapy

Mazziotti Gherardo , Bonadonna Stefania , Bugari Giovanna , Colao Annamaria , Cozzi Renato , Cannavo' Salvatore , De Marinis Laura , degli Uberti Ettore , Bogazzi Fausto , Minuto Francesco , Montini Marcella , Ghigo Ezio , Giustina Andrea

The effects of conventional somatostatin analog (SSA) regimens on glucose homeostasis seem to have minor clinical impact in acromegaly. Recently, we performed a trial showing that high dose octreotide LAR significantly reduces IGF1 in acromegalic patients uncontrolled with conventional SSA doses. In this post-hoc analysis, we evaluated the effects of high doses versus high frequency octreotide LAR on glucose homeostasis (HbA1c, FPG, HOMA-R) in patients with acromegaly e...

ea0020oc4.1 | Acromegaly/IGF1/Type 2 Diabetes | ECE2009

High-dose octreotide LAR in patients with acromegaly inadequately controlled by conventional somatostatin analogue therapy: a randomized, controlled trial

Giustina Andrea , Bonadonna Stefania , Bugari Giovanna , Colao Annamaria , Cozzi Renato , Cannavo Salvatore , De Marinis Laura , degli Uberti Ettore , Bogazzi Fausto , Mazziotti Gherardo , Minuto Francesco , Montini Marcella , Ghigo Ezio

Objective: In acromegaly, 25–50% of patients remain uncontrolled with conventional somatostatin analogue (SA) therapy. Evidence suggests that response may be improved by increasing the dose or frequency of administration of SAs. This study evaluated the efficacy and safety of octreotide LAR administered at a high dose or high frequency in patients with acromegaly.Methods: This was a 24-week prospective, multicenter, randomized, open-label trial in p...

ea0032p865 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effects of somatostatin analogues on muscle sympathetic nerve activity in acromegaly

Carzaniga Chiara , Seravalle Gino , Attanasio Roberto , Grassi Guido , Cozzi Renato , Maria Fatti Letizia , Montini Marcella , Vitale Giovanni , Sciortino Giovanna , Damanti Sarah , Scacchi Massimo , Mancia Giuseppe , Cavagnini Francesco , Persani Luca

Introduction: While searching for mechanisms contributing to the increased mortality of acromegaly, we have previously described an unexpected sympathoinhibition in newly diagnosed patients (Seravalle et al., Clin Endocrinol 77:262, 2012) and interpreted this finding as an adaptive phenomenon. It has also been shown that centrally administered somatostatin (SS) inhibits peripheral sympathetic outflow in rodents (Rettig et al., Am J Physiol 257:R588, 1989). Ba...

ea0022oc3.6 | Pituitary | ECE2010

Young patients with sporadic macroadenomas as target population for AIP mutations screening

Tichomirowa Maria , Barlier Anne , Daly Adrian , Jaffrain-Rea Marie-Lise , Cozzi Renato , Yaneva Maria , Naves Luciana , Ronchi Christina , Sievers Caroline , Maiter Dominique , Montanana Carmen Fajardo , Zacharieva Sabine , Beckers Albert

Methods: We undertook an assessment of patients which were diagnosed with or had their first symptoms of pituitary tumor before the age of 30 and had tumor diameter more than 1 cm without familial history of pituitary adenomas. In patients that consented to genetic analysis, germline mutations in the AIP gene were sought.Results: The study population consisted of 164 patients (61 prolactinomas, 84 somatotropinomas, 16 non-secreting tumors, two pat...

ea0016p733 | Thyroid | ECE2008

The role of pentagastrin stimulated calcitonin in nodular thyroid disease: will we be able to minimize false positive results?

Grossrubatscher Erika , Ciaramella Paolo Dalino , Carioni Emanuela , Cozzi Renato , Dallabonzana Daniela , Muratori Fabrizio , Oppizzi Giuseppe , Riolo Angela , Verde Giuseppe , Boniardi Marco , Pugliese Raffaele , Rossetti Ornella , Burla Teresa , Loli Paola

An increase in basal and Pentagastrin (Pg) stimulated calcitonin (CT) concentration is a specific feature of medullary thyroid carcinoma (MTC). Routine basal CT measurement in nodular thyroid diseases is controversial. Pg stimulation is expected to increase the basal CT specificity in MTC screening, although false positive responses in patients without MTC have been reported.Aim: To report the diagnostic accuracy of Pg-stimulated CT in surgically treated...