Searchable abstracts of presentations at key conferences in endocrinology

ea0032p207 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Subclinical atherosclerosis and cardiovascular risk in healthy, young menopausal women

Armeni Eleni , Stamatelopoulos Kimon , Georgiopoulos Georgios , Kouskouni Evangelia , Creatsa Maria , Alexandrou Andreas , Papamichael Christos , Lambrinoudaki Irene

Introduction: Delayed diagnosis of a cardiovascular event is related with higher case-fatality rate in women as compared to men. In fact, accumulating evidence supports an association between the menopausal status and the development of cardiovascular disease (CVD). We aimed to assess the extent of subclinical vascular disorders in young, healthy postmenopausal women, with respect to the calculated cardiovascular risk.Methods: This cross-sectional study ...

ea0022p150 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Genetic polymorphisms associated with cardiovascular risk correlate with dyslipidaemia in healthy postmenopausal women

Papadimitriou Dimitra , Kaparos George , Rizos Dimitrios , Armeni Eleni , Creatsa Maria , Alexandrou Andreas , Christodoulakos George , Lambrinoudaki Irene

Objective: To assess the impact of genetic polymorphisms associated with increased cardiovascular risk on the lipid profile in healthy postmenopausal women.Methods: The study population consisted of 84 women between 49–69 years who had been menopausal for at least one year. The genetic polymorphisms examined were the following: Glycoprotein IIIa leu33pro, Apolipoprotein E2/E3/E4, Methylenotetrahydrofolate reductase ala222val, Apolipoprotein B arg350...

ea0022p461 | Female reproduction | ECE2010

Estrogen plus progestin treatment: effect of different progestin components on serum markers of apoptosis in healthy postmenopausal women

Karaflou Maria , Kaparos George , Rizos Demetrios , Logothetis Emanuel , Alexandrou Andreas , Aravantinos Leon , Creatsa Maria , Christodoulakos George , Lambrinoudaki Irene , Kouskouni Evangelia

Objective: To investigate the effect of two hormone therapy (HT) regimens differing only in their progestin component on serum markers of apoptosis.Design: Randomized, double-blinded study.Patients: One hundred healthy postmenopausal women.Interventions: Patients were randomized to 17β-estradiol 1 mg/drosperinone 2 mg (E2/DSP) or 17β-estradiol 1 mg/norethisterone acetate 0.5 mg (E2</...

ea0022p462 | Female reproduction | ECE2010

The effect of hormone therapy and tibolone on serum CD40L and ADAM-8 in healthy postmenopausal women

Lambrinoudaki Irene , Karaflou Maria , Kaparos George , Grigoriou Odysseas , Alexandrou Andreas , Panoulis Constantinos , Logothetis Emanuel , Creatsa Maria , Christodoulakos George , Kouskouni Evangelia

Background/aim: The role of neutrophils and platelets in atherothrombotic disease is well established. The aim of our study was to investigate the effect of hormone therapy and tibolone on the soluble markers of neutrophil and platelet activation, ADAM-8 and CD40L respectively, in healthy postmenopausal women.Subjects and methods: One hundred and six healthy postmenopausal women were randomly allocated to: estradiol plus drospirenone (E2/DSP),...

ea0032p187 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

TSH and arterial stiffness in healthy postmenopausal women

Armeni Eleni , Stamatelopoulos Kimon , Rizos Demetrios , Georgiopoulos Georgios , Kazani Maria , Alexandrou Andreas , Deligeoroglou Efthymios , Livada Alexandra , Psychas Charalampos , Creatsa Maria , Bouboulis George , Alevizaki Maria , Lambrinoudaki Irene

Introduction: Thyroid dysfunction, whether overt or subclinical, has a significant effect on the cardiovascular system. On the other hand, fluctuation of thyroid hormones within the normal range has been associated with long-term health risks, and might have an impact on the vasculature. This study assessed the effect of thyroid hormones on surrogate markers of arterial structure and function in a sample of euthyroid postmenopausal women.Methods: This cr...

ea0022p735 | Steroid metabolism &amp; action | ECE2010

Effect of body mass index on differences of sex hormone levels in postmenopausal women receiving low-dose hormone therapy

Lambrinoudaki Irene , Armeni Eleni , Rizos Demetrios , Kofinakos Panagiotis , Kaparos George , Alexandrou Andreas , Creatsa Maria , Logothetis Emanuel , Papadimitriou Dimitra , Tsakonas Efstratios , Kouskouni Evangelia

Objective: To investigate the effect of BMI on the absolute change from baseline levels in circulating sex hormone in postmenopausal women treated with oral continuous combined low dose HT for 6 months.Design: The study recruited 36 postmenopausal women who received daily E2 1 mg/NETA 0.5 mg for 6 months. Hormonal assessment included measures of serum concentrations of FSH, LH, 17β-estradiol and free estrogen index (FEI), total and free testosterone...