Endocrine Abstracts

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Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder and contributes to excess morbidity and mortality in the populations affected. In developed healthcare systems PHPT is routinely diagnosed at the asymptomatic stage. Parathyroidectomy is the only curative treatment. The latest guidelines specific to the surgical management of patients with asymptomatic PHPT have been developed by the Fourth International Workshop. This audit aimed to establish how m...

Background: Zoledronic acid infusions are licensed for the treatment of osteoporosis and other bone disorders. Hypocalcaemia, a common side effect, increases the risk of complications. The risk of hypocalcaemia is further increased by a deficiency in 25-OH Vitamin D (VD). Pre-dose screening (PDS) is necessary to detect sub-optimal levels of serum VD and adjusted calcium (AC) early to avoid delayed treatment.Objectives: Audit adhere...

Aim: To evaluate the prevalence of kidney stones and osteoporosis in a cohort of patients with a confirmed diagnosis of primary hyperparathyroidism (PHPT).Study Design: This retrospective study reviewed the clinical records of patients with a confirmed diagnosis of PHPT in a single tertiary referral centre for metabolic bone disease over a period of 6 years (January 2010 – December 2015).Patients: There ...

Background: Zoledronic acid infusions are licensed for the treatment of osteoporosis and other bone disorders. Hypocalcaemia, a common side effect, increases the risk of complications. The risk of hypocalcaemia is further increased by a deficiency in 25-OH Vitamin D (VD). Pre-dose screening (PDS) is necessary to detect sub-optimal levels of serum VD and adjusted calcium (AC) early to avoid delayed treatment.Objectives: Audit adhere...

Aim: To evaluate the prevalence of kidney stones and osteoporosis in a cohort of patients with a confirmed diagnosis of primary hyperparathyroidism (PHPT).Study Design: This retrospective study reviewed the clinical records of patients with a confirmed diagnosis of PHPT in a single tertiary referral centre for metabolic bone disease over a period of 6 years (January 2010 – December 2015).Patients: There ...

Adult growth hormone deficiency (AGHD) is a metabolic syndrome characterised by osteoporosis, increased visceral fat, adverse lipid profiles, decreased muscle mass and reduced energy levels. As such, it is associated with reduced quality of life (QoL) and increased mortality from cardiovascular disease. Synthetic growth hormone (GH) can be given to replace natural GH; however, treatment is costly at around £3350 per patient per year and could cause side effects including ...

Background: It is well established that patients with acromegaly have compromised quality of life both during active disease, as well as whilst on remission. (1). In the recent years, there has been increasing emphasis on the importance of considering health-related quality of life (QoL) outcomes in the care of patients with acromegaly. The University Hospitals Birmingham NHS Foundation Trust introduced and implemented the use of a holistic needs assessm...

Background: It is well established that patients with acromegaly have compromised quality of life both during active disease, as well as whilst on remission. (1). In the recent years, there has been increasing emphasis on the importance of considering health-related quality of life (QoL) outcomes in the care of patients with acromegaly. The University Hospitals Birmingham NHS Foundation Trust introduced and implemented the use of a holistic needs assessm...

A 29 year old gentleman presented to Urology with scrotal pain. He had renal calculi but examination also revealed small testicles for which he was referred to Endocrinology. He achieved normal developmental milestones. He had no history of mumps or testicular torsion or surgery. He had no history of hypospadias or undescended testicles. He was not on any regular medication and denied anabolic steroids use. He reported a normal sense of smell. His body weight was 72 Kg with he...