Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1120 | Female Reproduction | ECE2017

Global methylation pattern and endocrine-metabolic profile during early infancy and puberty in sons born to women with polycystic ovary syndrome (PCOS)

Sir-Petermann Teresa , Crisosto Nicolas , Echiburu Barbara , Maliqueo Manuel , Perez-Bravo Francisco , Sandoval Daniel , Recabarren Sergio

Prenatal and postnatal environment can regulate gene expression through multiple epigenetic mechanisms, being DNA methylation among the most relevant. Metabolic and reproductive function may be modified by this mechanism. Sons born to women with PCOS show altered markers of metabolic and reproductive function during childhood and adulthood. However, these functions have not been studied during puberty. The aim of the present study was to assess the global methylation pattern a...

ea0037gp.06.05 | Reproduction: Female and PCOS | ECE2015

Cytokine expression in SAT and VAT from PCOS patients and control women; possible proinflammatory effect of testosterone depending on BMI – a preliminary report

Crisosto Nicolas , Echiburu Barbara , Perez-Bravo Francisco , Flores Cristian , Fuentes Cecilia , Cifuentes Mariana , Orellana Omar , Maluenda Fernando , Sir-Petermann Teresa

Context: Insulin resistance is an important component of polycystic ovary syndrome (PCOS). Local cytokine production in adipose tissue increases local insulin resistance. The effect of testosterone on local adipose tissue cytokine production has not been explored thoroughly.Aim: To evaluate cytokine expression in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from PCOS and control women and evaluate the response to testosterone on th...

ea0032p597 | Female reproduction | ECE2013

Metabolic features in patients with polycystic ovary syndrome (PCOS) during different stages of reproductive life

Sir-Petermann Teresa , Ladron de Guevara Amanda , Echiburu Barbara , Crisosto Nicolas , Vantman Natalie , Pereira Cecilia , Perez-Bravo Francisco , Galgani Jose

Polycystic ovary syndrome (PCOS) is an important metabolic and reproductive disorder which confers substantially increased risk for type two diabetes and metabolic syndrome (MS). Our aim is to characterize the metabolic profile, insulin sensitivity (IS) and insulin secretion in control (Cw) and PCOS women (PCOSw) during different stages of reproductive life (S1: 18–35 years old, S2: 36–44 years old, S3: 45–55 years old). A total of 131 Cw and 129 PCOSw were incl...

ea0056gp163 | Paediatrics, Developmental ' Female Reproduction | ECE2018

Global DNA methylation since early infancy to adulthood in the offspring of women with polycystic ovary syndrome (PCOS)

Sir-Petermann Teresa , Echiburu Barbara , Maliqueo Manuel , Perez-Bravo Francisco , Crisosto Nicolas , Flores Cristian , Sandoval Daniel , Recabarren Sergio E

DNA methylation is an epigenetic mechanism of gene regulation that can be modified during intrauterine and postnatal life. Pregnant women with polycystic ovary syndrome (PCOS) present elevated androgen and insulin levels, which can affect the DNA methylation pattern of their offspring. Then, we studied the global DNA methylation pattern (GDNAm) in daughters and sons born to PCOS women compared to controls. Daughters (99 born to PCOS and 87 born to control women) and sons (74 b...

ea0041ep1110 | Thyroid cancer | ECE2016

Comparisson between two differnet protocols for the management of patients with differnetiated thyroid cancer

Crisosto Nicolas , Inostroza Vjeroka , Campos Cristian , Gajardo Francisca , Invernizzi Pamela , Vasquez Felix , Hernandez Paola , Pereira Cecilia , de Guevara Amanda Ladron , Dominguez Miguel , Diaz Erika

Introduction: New techniques such as etapification ecotomography (EE) have led to less invasive surgeries in Differentiated Thyroid Cancer (DTC). The trend in recent years has been to a reduction in the doses of radioiodine administered. Our hospital in 2013 incorporated these features to protocolize the administration of radioiodine depending on the characteristics of the tumour and the initial thyroglobulin levels, which may have had an impact in the response to treatment (R...

ea0041ep1152 | Thyroid cancer | ECE2016

Local classification of differentiated thyroid cancer: does it help to discriminate the response to treatment?

Gajardo Francisca , Pereira Cecilia , Campos Cristobal , Inostroza Vieroska , Diaz Erika , Invernizzi Pamela , Vasquez Felix , Crisosto Nicolas , de Guevara Amanda Ladron , Hernandez Paola , Dominguez Miguel

Introduction: The prediction of the risk of recurrence in differentiated thyroid cancer (dtc) in chile is different from ata. The use of the stimulated thyroglobulin (tg) post-surgery in the prediction of the risk is controversial. We present a cohort applying a new local protocol that includes the tg for supporting the discrimination of the patients for offer low doses or radio iodine.Objective: Asses if the local risk classification (lc) allow us to di...

ea0081p189 | Reproductive and Developmental Endocrinology | ECE2022

Is there a link between polycystic ovary syndrome and transgenerational transmission of a reproductive and metabolic function in male offspring?

Risal Sanjiv , Li Congru , Luo Qing , Fornes Romina , Manti Maria , Lu Haojiang , Eriksson Gustaw , Ohlsson Claes , Lindgren Eva , Crisosto Nicolas , Maliqueo Manuel , Echiburu Barbara , Recabarren Sergio , Sir Petermann Teresa , Benrick Anna , Brusselaers Nele , Qiao Jie , Deng Qiaolin , Stener-Victorin Elisabet

Our previous study showed that polycystic ovary syndrome (PCOS)-like reproductive and metabolic phenotypes induced by maternal dihydrotestosterone (DHT)-exposure, can be passed on in mice from mothers (F0) to daughters (F1), granddaughters (F2), and even to great-granddaughters (F3). The female transmission is independent of diet-induced obesity and is mediated by transcriptional and mitochondrial perturbations of oocytes accompany. ...