Endocrine Abstracts

Introduction: Central pontine myelinolysis (CPM) is a rare and potentially life-threatening complication of a sudden rise in serum osmolality. Along with extrapontine myelinolysis, it is part of the osmotic demyelination syndrome (ODS). Known risk factors include severe hyponatremia, alcoholism, thiazide use, hypokalemia, and malnourishment.Case report: We report the case of a 31-year-old-male with history of alcohol and cannabis dependence, who had atte...

IntroductionGraves’ Disease is an autoimmune syndrome that include hyperthyroidism, goiter, thyroid eye disease, and occasionally, a dermopathy called pretibial or localized myxedema. As each autoinmune ailment to develop in sufferers with genetic susceptibility after a certain environmental exposure (infection, stress…). COVID-19 can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. Since the out...

Diabetes and acute hyperglycemia are known to increase stroke volume and disability in stroke patients, and deliver worse outcomes after reperfusion therapies. Chronic glycemic status has recently been linked to stroke functional outcome, but its impact on long term prognosis of stroke has rarely been studied. We conducted a study to investigate the impact of glycosylated hemoglobin (HbA1c) levels on functional outcome 1 year after stroke.Methods: Patien...

Introduction: The most common cause of hyponatraemia is the syndrome of inappropriate antidiuretic hormone (SIADH). The diagnosis typically requires hyponatraemia in the setting of reduced serum osmolality, inappropriately concentrated urine with normal sodium excretion levels, and the absence of interfering medications, hypothyroidism and adrenal insufficiency. Unless hypertonic saline is indicated for acute onset profound hyponatraemia and/or with severe symptoms, the mainst...

Selpercatinib is a receptor tyrosine kinase RET inhibitor for the treatment of cancers such as RET-mutant medullary thyroid cancer, demonstrating partial response and low incidence of serious adverse events. Vandetanib, a tyrosine kinase inhibitor, has shown promising results with an increase in progression-free survival and prolonged lifetime, but it causes adverse events such as hypertension, diarrhea, rash, or long QT interval. Most of them are can be even disabling for the...