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ea0099ep327 | Adrenal and Cardiovascular Endocrinology | ECE2024

Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas (ACC)

Catalano Rosa , Nozza Emma , Esposito Emanuela , Maria Barbieri Anna , Croci Giorgio , Altieri Barbara , Angelousi Anna , Luconi Michaela , Constanze Hantel , Sigala Sandra , Landwehr Laura-Sophie , Di Dalmazi Guido , Cassinotti Elisa , Baldari Ludovica , Palmieri Serena , Mangone Alessandra , Ferrante Emanuele , Ronchi Cristina , Mantovani Giovanna , Peverelli Erika

Adrenocortical carcinomas (ACC) overexpress the insulin-like growth factor 2 (IGF2) that drives a proliferative autocrine loop by binding both IGF1R and isoform A of insulin receptor (IRA). However, the contribution of these receptors in mediating ACC cell growth has been poorly investigated. The aim of this study was to investigate IGF1R and IR expression and localisation in ACC and adrenocortical adenomas (ACA) samples, and to test their involvement in mediating IGF2 tumorig...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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