Searchable abstracts of presentations at key conferences in endocrinology

ea0011p38 | Bone | ECE2006

Glucocorticoid metabolism in mouse osteoblasts: a model for the effects of local glucocorticoid generation on bone

Crook R , Hewitt K , Stewart PM , Rabbitt EH , Cooper MS

Human studies have suggested that local glucocorticoid (GC) generation within osteoblasts plays a critical role in bone loss seen during aging, in response to inflammation and treatment with GCs. Human osteoblasts express the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) that converts inactive GCs (cortisone, dehydrocorticosterone, prednisone) to their active counterparts (cortisol, corticosterone, prednisolone). Enzyme expression increases with age, in r...

ea0009p189 | Clinical | BES2005

Myelinolysis following the treatment of Addisonian crisis

Lockett H , Smith J , Dyer R , Crook N

Myelinolysis is a recognised complication following over-rapid correction of hyponatraemia. However, the risk of myelinolysis following the treatment of Addisonian crisis is rarely reported. We report 2 cases of primary adrenal insufficiency (PAI) both associated with severe hyponatraemia. In the first case, myelinolysis developed following treatment with corticosteroids and isotonic saline in line with current recommendations. In the second case, deliberately cautious correct...

ea0009p72 | Growth and development | BES2005

IL-1 and glucocorticoids synergistically enhance 11beta-hydroxysteroid dehydrogenase expression in osteoblastic MG-63 cells: a novel mechanism for steroid induced bone loss

Kaur K , Crook R , Bujalska I , Cooper M , Stewart P , Hewison M

Glucocorticoids (GCs) are important therapeutic agents for a wide-variety of inflammatory diseases but are known to have potentially detrimental side-effects such as osteoporotic bone-loss. These effects of GCs are mediated via the intracellular GC receptor (GR) and by local GC metabolism catalyzed by 11beta-hydroxysteroid dehydrogenase (11beta-HSD). We have postulated that autocrine activation of GCs via 11beta-HSD1 plays a key role in counteracting the effects of inflammator...