Searchable abstracts of presentations at key conferences in endocrinology

ea0014p137 | (1) | ECE2007

A novel role for Visfatin/Pre-B cell colony-enhancing factor 1 (PBEF)/Nicotinamide phosphoribosyltransferase (NMPRTase) in prostate carcinogenesis

Mistry Tina , Digby Janet , Cross Joe , Desai Ken , Randeva Harpal

Introduction: Visfatin/PBEF is a novel adipokine circulating inversely proportional to visceral fat mass and exerts insulin-mimetic effects; it is expressed in normal, inflamed and tumour tissues. Visfatin/PBEF has also been identified as NMPRTase, a key intracellular enzyme involved in NAD+ metabolism, replenishing NAD+ during cellular respiration. Inhibition of NMPRTase by the anti-cancer agent FK866 has been shown to induce apoptosis in tumours. Prosta...