Searchable abstracts of presentations at key conferences in endocrinology

ea0021p7 | Bone | SFEBES2009

Osteoporosis in a young cohort: aetiology and gender differences in referral for DXA

Ryan Stephen , Crowley Rachel K , Chavrimootoo Shawn , Harney Sinead , Tuthill Antoinette

In young patients osteoporosis is associated with endocrine and inflammatory conditions. Early identification of osteoporosis may reduce later morbidity.We aimed to establish the aetiology of low bone mineral density (LBMD) in young patients at our centre. We identified risk factors and impact of gender on BMD in a young at-risk cohort.All patients between 20 and 55 years old who underwent DXA scan between 2004 and 2009 were identi...

ea0015p206 | Neuroendocrinology and behaviour | SFEBES2008

High prevalence of sleep apnoea in craniopharyngioma patients after surgical intervention

Crowley Rachel K , Woods Conor , Fleming Michelle , Rogers Bairbre , Costello Richard W , Thompson Christopher J

Patients with craniopharyngioma have increased mortality attributed to cardiorespiratory disease, when compared to other hypopituitary populations. There is little data on the cause for excess of fatal respiratory disease in this condition. Clinical observation had identified sleep apnoea in some craniopharyngioma patients in our cohort. Sleep apnoea increases cerebrovascular and cardiovascular morbidity and mortality. Our hypothesis was that sleep apnoea could be a contributo...

ea0063p41 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Prevalence and prognosis of bone metastases in pancreatic and small intestinal neuroendocrine tumours

Mammadov Emin , Hughes Nicola , Alnuaimi Asma , Chin Jun Liong , O'Toole Dermot , O 'Shea Donal , Heffernan Eric , Crowley Rachel K

Background: Neuroendocrine tumours (NET) can affect various tissues and organs, have different clinical presentation and prognosis, depending on the primary tumour site, grading, differentiation and functional status. Reported prevalence of bone metastases (BM) from NETs has been increasing with improved imaging modalities, reaching >40% in some reports. The BM diagnosis is associated with reduced overall survival; however, this was not confirmed by all studies.<p clas...

ea0031p74 | Clinical practice/governance and case reports | SFEBES2013

Spironolactone interference in the immunoassay of androstenedione in a patient with a cortisol-secreting adrenal adenoma

Broderick Deirdre , Crowley Rachel K , O'Shea Triona , Boran Gerard , Conlon Kevin , Maher Vincent , Gibney James , Sherlock Mark

A 48-year-old man was referred for investigation of uncontrolled hypertension on four agents (olmesartan, felodipine, hydrochlorothiazide and spironolactone) and a 3 cm right-sided adrenal adenoma (pre-contrast Hounsfield units 25). Endocrine investigation for the hypertension and adrenal mass included: androstenedione 19.9 nmol/l 2.8–10.5) (elevated on two occasions on a Siemens Coat-A-Count assay), DHEA 0.7 μmol/l (2.1–15.2), 1 mg overnight dexamethasone suppr...

ea0015p213 | Neuroendocrinology and behaviour | SFEBES2008

Preservation of sexual dimorphism and diurnal variation in leptin levels of patients with craniopharyngioma

Crowley Rachel K , Woods Conor , Fleming Michelle , Rogers Bairbre , O'Sullivan Eoin P , Smith Diarmuid , Thompson Christopher J

Leptin is an adipocytokine with a role in appetite, energy expenditure and reproductive regulation. In normal, non-obese individuals, leptin levels are higher in females, independent of differences in body fat between the genders. High levels of leptin that were disproportionate to body mass index (BMI) have been reported in craniopharyngioma patients, thus we hypothesised that surgical resection and hypothalamic damage conferred leptin resistance on craniopharyngioma patients...

ea0015p240 | Pituitary | SFEBES2008

The short and long-term effect of growth hormone (GH) replacement therapy on quality of life in adults with severe growth hormone deficiency

Behan Lucy Ann , Rogers Bairbre , Connolly Cara , Burrows Samantha , O'Sullivan Eoin P , Crowley Rachel K , Smith Diarmuid , Agha Amar

Adult GH deficiency is associated with poor quality of life (QoL) which has been shown to improve with GH replacement is some but not all, mainly short-term studies. In addition, it remains unclear whether this improvement in QoL is sustainable.We aimed to establish the short and long-term effect of GH replacement on QoL in 167 adult patients with severe GH deficiency in a prospective study. QoL was assessed using the quality of life-assessment of growth...

ea0037ep744 | Pituitary: clinical | ECE2015

Symptoms of gonadal dysfunction are more predictive of hypopituitarism than non-specific symptoms in screening for pituitary dysfunction following moderate or severe traumatic brain injury

Hernandez Martin Cuesta , Hannon Mark J , Crowley Rachel K , Behan Lucy Ann , Tormey William , Rawluk Daniel , Delargy Mark , Agha Amar , Thompson Christopher J

Context: The economic and logistic burden of screening for hypopituitarism following moderate/severe traumatic brain injury (TBI) is considerable. Published guidelines suggest prioritisation for screening of patients with symptoms of pituitary dysfunction.Objective: To evaluate the implementation of targeted symptom-based screening for hypopituitarism after moderate/severe TBI, compared with routine consecutive screening.Design: Gr...

ea0021p270 | Pituitary | SFEBES2009

Hypothalamic resistance to signals of energy reserve, rather than excess appetite stimulation, may contribute to obesity in CP patients

Crowley Rachel K , Barrett Patricia , Woods Conor , Fleming Michelle , Behan Lucy Ann , O'Sullivan Eoin P , Rogers Bairbre , Agha Amar , Smith Diarmuid , Thompson Christopher J

Obesity is a recognised complication of craniopharyngioma (CP), but its aetiology is not understood. Leptin, which signals energy reserve, and ghrelin, which regulates appetite, are implicated in the development of obesity.Our aim was to assess leptin and ghrelin levels in CP patients and to compare these to normal and BMI-matched controls.CP patients were identified from the local database. All CP patients were on hormone replacem...

ea0056oc3.1 | New insights in bone disorders | ECE2018

A Phase 3 randomized, double-blind, placebo-controlled study investigating the efficacy and safety of Burosumab, an anti-FGF23 antibody, in adult X-Linked Hypophosphatemia (XLH)

Kamenicky Peter , Lachmann Robin , Carpenter Thomas O. , Cohen-Solal Martine , Eastell Richard , Brandi Maria Luisa , Crowley Rachel K. , Ralston Stuart H. , Javaid Muhammad K. , Keen Richard , Briot Karine , Il Cheong Hae , Imanishi Yasuo , Ito Nobuaki , Tanaka Hiroyuki , Zhang Lin , Theodore-Oklota Christina , Mealiffe Matt , Martin Javier San , Insogna Karl L.

UX023-CL303 is an ongoing, Phase 3, double-blind, multicenter study examining the efficacy and safety of burosumab, a fully human monoclonal antibody against FGF23, in adults with XLH. Eligible subjects had serum phosphorus levels <0.81 mmol/l and skeletal pain (BPI – Worst Pain ≥4). Subjects (N=134) were randomized 1:1 to receive burosumab 1 mg/kg or placebo subcutaneously every 4 weeks. After 24 weeks, subjects in the placebo group crossed-over to rec...