Searchable abstracts of presentations at key conferences in endocrinology

ea0024p54 | (1) | BSPED2010

Association of malaria in pregnancy with maternal metabolic biomarkers, cord blood IGF-I and birth size in Nigerian infants: ‘The Ibadan Growth and Vascular Health Study’

Ayoola O O , Whatmore A J , Cruickshank J K , Clayton P E

Malaria is commoner amongst pregnant than non-pregnant women in Nigeria and is associated with a significant risk of having a low birth weight (LBW) baby which increases later risk of disease, in particular hypertensive heart disease in this population.We have established a birth cohort in Nigeria and in this study; we aimed to identify possible biomarkers in maternal and/or cord blood related to birth size on the background of malarial status in pregnan...

ea0003p226 | Reproduction | BES2002

Significant ethnic variation in circulating total bound and free testosterone

Heald A , Bethell F , Anderson S , Owen D , Laing I , Gibson J , Cruickshank J

OBJECTIVE Measurement of serum testosterone level is an integral part of the assessment of men presenting to endocrine clinics. Little is known about variation of testosterone level by ethnic group. The principal determinant of testosterone bioavailability is sex hormone binding globulin (SHBG) which itself is a marker for insulin sensitivity. Our aim was to examine variations in testosterone and SHBG levels across three ethnic groups in relation to ethnic differences in insul...

ea0007oc33 | Diabetes and metabolism | BES2004

Dietary intake and the IGF-system: a study in two related populations with a markedly different dietary intake

Anderson S , Heald A , Vyas A , Siddals K , Patel J , Laing I , Bhatnagar D , Durrington P , Gibson J , Cruickshank J

IntroductionThe IGF-system has also been implicated in the pathogenesis of diabetes and cardiovascular disease. We report the effects of total energy intake on the IGF-system in two populations with a markedly different dietary macronutrient intake and cardiovascular event rate.MethodDietary macronutrient intake was measured in a specific Gujarati migrant community in Sandwell UK (n=205) compared with people ...

ea0005p87 | Diabetes, Metabolism and Cardiovascular | BES2003

Circulating IGFBP-3 concentration is independently associated with insulin resistance and BMI

Heald A , Anderson S , Cruickshank J , Gibson J

IntroductionRecent studies have confirmed that IGF-I is an important determinant of future glucose homeostasis and cardiovascular risk. Insulin-like growth factor binding protein-3 (IGFBP-3) is the principal carrier protein for IGF-I in the circulation. Therefore we tested the relationship of IGF-I and IGFBP-3 to insulin resistance in an ethnic group with a high incidence of type 2 diabetes and cardiovascular disease.Methods. In a population-based study 100 subjects of...

ea0030p39 | (1) | BSPED2012

The impact of malaria in pregnancy on changes in blood pressure in children over the first year of life

Ayoola Omolola , Omotade Olayemi , Gemmell Isla , Clayton Peter , Cruickshank J Kennedy

Introduction: As in most sub-Saharan Africa, hypertension and its complications are increasingly common in Nigeria, where malaria is hyper-endemic. We established a birth cohort in Ibadan to assess the impact of maternal malaria on blood pressure (BP) in Nigerian infants over their first year.Methods: Healthy pregnant women with singleton pregnancies were followed to delivery. They had regular blood films for malaria parasites through to delivery. Growth...

ea0007p52 | Diabetes, metabolism and cardiovascular | BES2004

The IGF system influences prevalence of the metabolic syndrome in a population with high rates of cardiovascular disease

Heald A , Anderson S , Vyas A , Patel J , Siddals K , Cruickshank J , Gibson J

IntroductionThe metabolic syndrome is associated with an increased risk of cardiovascular disease and diabetes. The insulin-like growth factor (IGF) system has been implicated in the pathogenesis of cardiovascular disease and glucose intolerance. We have previously shown that a low IGFBP-1 concentration coupled with a low circulating IGF-I predicts worsening glucose tolerance. In this study we further investigated relationships between the IGF-system and...