Searchable abstracts of presentations at key conferences in endocrinology

ea0011p216 | Comparative endocrinology | ECE2006

Short-term effects of propionate on the leptin system and on G protein-coupled receptor GPR41 mRNA levels in adipose tissue of goats

Mielenz MM , Seybold CS , Sauerwein HS

Propionate upregulates leptin synthesis through the G protein-coupled receptor 41 (GPR41) in mice. In contrast to monogastric mammals, ruminants almost entirely depend on short chain fatty acids as energy source, but the reports about the physiological relevance of propionate for leptin secretion in these species are controversial and the importance of the GPR41 for its regulation is not yet clarified. Here we characterise the effects of intravenously infused propionate on the...

ea0008p77 | Reproduction | SFE2004

Do Androstenedione and DHEAS contribute to the diagnosis of PCOS in GP Patients?

Noyce CS , Talbot RM , Armston AE

Aims: To discover if the addition of DHEAS (dehydroepiandrosterone sulphate) and androstenedione aids diagnosis in GP patients with PCOS (polycystic ovary syndrome) as part of their differential diagnosis.Methods: Over two months our laboratory received seventy-nine female General Practice patients whose symptoms / signs led to a differential diagnosis including PCOS. Of these, nine had a raised total testosterone and twenty-seven had a raised free andro...

ea0013p287 | Steroids | SFEBES2007

Unusually mild phenotypic presentation in a family with CYP17A1 deficiency detected by urinary steroid profiling

Arun CS , Ivison HE , Taylor Norman , Arlt Wiebke , Cheetham Tim

The human CYP17A1 enzyme exerts two activities, 17a-hydroxylase and 17,20 lyase, catalysing key steps in human adrenal steroid biosynthesis. An in frame deletion of 3 bp in exon 1 of the CYP17A1 gene, resulting in the loss of phenylalanine in position 53 (F53del), is one of the first CYP17A1 mutations described (JBC 1989, 264:18076). Reported patients have invariably presented with severe hypokalaemic hypertension, reflecting 17α-hydoxylase deficiency, and s...

ea0026p340 | Obesity | ECE2011

Long term low intensity recreational physical exercise attenuates colonic inflammation in rats: the role of heme oxygenase system

Szalai Z , Berko A M , Posa A , Szabo R , Orban K , Kiraly A , Laszlo F , Varga Cs

Introduction: Obesity caused health problems are increasing. Metabolic syndrome including obesity with insulin resistance, hypertension, and high blood lipid levels increases the risks of cardiovascular and inflammatory diseases. Many studies have reported that heme oxygenase (HO) inducers reduce insulin resistance and severity of inflammatory bowel disease. We investigate the anti-inflammatory effect, one among many positive effects, of regular recreational physical activity ...

ea0014oc10.3 | Obesity & metabolism | ECE2007

Selective leptin resistance within the brainstem of histamine deficient mice

Földes Anna , Márkus Veronika , Kovács Krisztina

Histamine is an important anorexic factor that suppresses food intake via hypothalamic H1 receptors and increases energy expenditure by stimulating lipolysis. Mice with targeted deletion of the key enzyme of histamine biosynthesis, histidine decarboxylase (HDC-KO), are unable to synthesize histamine. These animals display a metabolic phenotype with adult onset obesity, selective increase in visceral fat depots, impaired glucose tolerance and hyperleptinemia. To test the possib...

ea0012oc21 | Pituitary, ovary and steroids | SFE2006

Macroprolactinoma with progressive resistance to high-dose cabergoline

Arun CS , Mitra Dip , Ball Steve , Hill John , Lewis Joanna , Quinton Richard

IntroductionTrue resistance to cabergoline in patients with hyperprolactinaemia has only rarely been reported. We describe a patient with macroprolactinoma who initially responded to cabergoline, but then developed a progressive increase in PRL levels.Clinical caseA 78-year-old male presenting with headache and left temporal hemianopia was found to have a macroprolactinoma with suprasellar/cavernous sinus ext...

ea0011p591 | Neuroendocrinology and behaviour | ECE2006

Evaluation of cognitive functions by using p300 auditory event related potentials (ERPs) in patients with growth hormone (GH) deficiency and gh excess

Tanriverdi FT , Suer CS , Yapislar HY , Unluhizarci KU , Bayram FB , Kelestimur FK

Objective: Impaired cognitive function has been demonstrated in adults with GH deficiency (GHD) and acromegaly by using different neuropsychological tests. P300 ERP application is a well established neurophysiological approach in the assessment of cognitive function. However the comparison of the P300 ERPs between GHD and GH excess have not been done yet. The present study was designed to investigate the effects of GHD and acromegaly on cognitive function by using P300 ERPs.</...

ea0008oc12 | Neuroendocrinology and Reproduction | SFE2004

Macrophage migration inhibitory factor is released from pituitary folliculo-stellate-like cells by endotoxin and dexamethasone and attenuates the steroid-induced inhibition of interleukin 6 release

Tierney T , Patel R , Stead CS , Leng L , Bucala R , Buckingham JC

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine produced by peripheral immune cells and also by pituitary endocrine cells. MIF exerts its pro-inflammatory actions in the host defence system by blocking the inhibitory effects of glucocorticoids on the release of other pro-inflammatory cytokines. Reports that pituitary folliculo-stellate (FS) cells show characteristics of immune cells led us to propose that FS cells may serve as an additional source o...

ea0070aep46 | Adrenal and Cardiovascular Endocrinology | ECE2020

Fertility testing in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Szücs Nikolette , Tőke Judit , Reismann Péter , Doleschall Márton , Patócs Attila , Riesz Péter , Tóth Miklós

Introduction: Congenital adrenal hyperplasia (CAH) is an autosomal recessively inherited disorder resulting from the mutations of one of Seven genes involved in adrenal steroidogenesis. The consequent enzyme defects lead to defects of varying severity of steroid biosynthesis. Patients require lifelong substitution treatment and endocrine care.Objectives: One of the many consequences of CAH is reduced fertility. The aim of this study was to investigate th...