ea0014p130 | (1) | ECE2007
Dardano Angela
, Ferrari Davide
, Cuccato Sabina
, Santini Eleonora
, Caraccio Nadia
, Gulinelli Sara
, Callegari Giulia
, Faviana Pinuccia
, Solini Anna
, Di Virgilio Francesco
, Monzani Fabio
Extracellular ATP modulates several biological processes via activation of plasma membrane receptors (P2Rs) in normal human thyrocytes (NT). We characterized P2Rs expression and function in two thyroid cancer cell lines: FB1 (anaplastic cancer) and FB2 [papillary cancer (PTC)]. P2Rs expression was evaluated by RT-PCR and WB, intracellular Ca2+changes by fluorimetric technique (Fura2-AM), IL-6 release by ELISA, intracellular [i(ATP)] and extracellular ATP [...