Searchable abstracts of presentations at key conferences in endocrinology

ea0061p002 | (1) | OU2019

Metabolic changes post Roux-En-Y Gastric Bypass: one year prospective study

Alexiadou Kleopatra , Behary Preeshila , Cuenco Joyceline , Tharakan George , Anyiam Oluwaseun , Hope David , Alessimii Haya , Choudhury Sirazum , Doyle Chedie , Rabie Ahmad , Ahmed Ahmed , Bloom Steve , Tan Tricia

Background: Bariatric surgery is currently the most effective treatment for weight loss. Its metabolic effects of weight loss and improvement of type 2 diabetes are mediated mainly through the postprandial elevation of gut hormones such as GLP-1, which suppresses food intake and improves insulin secretion.Aim: To characterize the longitudinal changes in fasting and postprandial secretion of glucose, insulin and gut hormones (GLP-1 and GIP) in patients be...

ea0067o24 | Oral Presentations | EYES2019

Proglucagon peptide family responses after RYGB surgery in obese patients with type 2 diabetes

Alexiadou Kleopatra , Cuenco Joyceline , Howard James W , Fleuret Matthieu , Behary Preeshila , Tharakan George , Albrechtsen Nicolai J Wewer , Holst Jens Juul , Pembroke Jason , Wheller Robert , Ahmed Ahmed R , Bloom Steve R , Tan Tricia M

Objective: Bariatric surgery is currently the most effective treatment for weight loss and diabetes remission. There are conflicting reports in the literature regarding the glucagon levels after RYGB surgery, likely due to cross-reactivity with oxyntomodulin and glicentin. The aim of this study was to characterize the proglucagon peptide family responses post-RYGB surgery in obese patients with type 2 diabetes using validated assays.Method: Nineteen obes...

ea0070aep281 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The MAFA gene mutation responsible for familial insulinomatosis and diabetes impairs insulin secretion and results in downregulation of critical cell cycle regulators

Iacovazzo Donato , Thong Lim Chung , Quezado Rosana , Drummond Juliana , Antonio de Sousa Barros Fernando , Cuenco Joyceline , Brändle Michael , Walker Emily , Guo Min , Collier David , Khan Faraz , Wang Jun , Tan Tricia , Ellard Sian , Stein Roland , Korbonits Marta

The islet-enriched transcription factor MAFA regulates the expression of genes critical to beta cell function and insulin secretion. We previously described anovel MAFA mutation (c.191C > T, p.S64F) causing familial insulinomatosis and diabetes mellitus, with male carriers more often developing diabetes and females more prone to insulinomatosis. The exact molecular mechanisms underlying these phenotypes are unclear. In this study, we assessed glucose metabolism an...

ea0031oc4.5 | Obesity, metabolism and bone | SFEBES2013

Energy intake following infusion of glucagon and GLP-1: a double-blind crossover study

Cegla Jaimini , Troke Rachel , Jones Ben , Tharakan George , McCullough Katherine , Wilde Julia , Lim Chung Thong , Parvizi Naseem , Hussein Mohamed , Minnion James , Cuenco Joyceline , Chambers Edward , Ghatei Mohammad , Tan Tricia , Bloom Stephen

Obesity is a growing global epidemic and current medical therapies have proven inadequate. Endogenous satiety hormones provide an attractive target for the development of drugs which aim to cause effective weight loss with minimal side effects. Two related peptide hormones, glucagon and glucagon-like peptide 1 (GLP-1), are the subject of this investigation. Both have been found to reduce appetite and cause weight loss. Additionally, glucagon increases energy expenditure. It is...