Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep685 | Pituitary and Neuroendocrinology | ECE2020

High prevalence of pituitary deficiency after cranial radiation therapy for skull base meningioma: The importance of an annual screening.

Raymond Perrine , Cuny Thomas , Klein Marc , Bernier-Chastagner Valerie

Purpose: To determine the risk of developing hypopituitarism after cranial irradiation for skull base meningiomas. Cranial irradiation is often chosen as first treatment in skull base meningiomas to avoid risk to proximally-located critical structures. While cranial irradiation has been associated with high risk of inducing hypopituitarism, few studies concern meningiomas.Methods and materials: Fifty-two adult patients receiving photon-beam therapyfor sk...

ea0081rc6.2 | Rapid Communications 6: Endocrine-Related Cancer | ECE2022

Reciprocal interactions between fibroblast and pancreatic neuroendocrine tumor cells: putative impact of the tumor microenvironment

Cuny Thomas , Mondielli Gregoire , van Koetsveld Peter , de Herder Wouter , Barlier Anne , Hofland Leo

Introduction: Pancreatic neuroendocrine neoplasms (PNEN) present with a fibrotic stroma which constitutes the tumor microenvironment (TME). The role played by stromal fibroblasts over the growth of PNEN and their sensitivity to the mTOR inhibitor, RAD001, are as yet unestablished.Methods: We investigated reciprocal interactions between 1) human PNEN cell lines (BON-1/QGP-1) or primary cultures of human ileal neuroendocrine neoplasm (iNEN) or PNEN, and 2)...

ea0063oc7.4 | Endocrine Connections 1 | ECE2019

Non-invasive detection of GNAS mutations causing McCune-Albright Syndrome with ddPCR on whole blood or circulating DNA

Romanet Pauline , Philibert Pascal , Fina Frederic , Cuny Thomas , Reynaud Rachel , Paris Francoise , Barlier Anne

Context: Postzygotic activating mutations in GNAS are responsive for fibrous dysplasia (FD) and McCune-Albright Syndrome (MAS). MAS is a rare disease associating fibrous dysplasia, to skin pigmentation and endocrine disorders. The classic genetic non-invasive methods are insufficiently sensitive to detect GNAS mutation, due to a low level of mosaicism in blood. Early diagnostic should allow a follow-up and a therapeutic choice adapted to the MAS context in or...

ea0073aep844 | Late Breaking | ECE2021

The relative’s viewpoint on acromegaly in remission : A psychosocial dimension of a chronic disease

Fourneaux Rachel , Marie Vermalle , Albarel Frederique , Morange Isabelle , Graillon Thomas , Amodru Vincent , Cuny Thomas , Dufour Henry , Brue Thierry , Castinetti Frederic

Aim of the studyA relative can be an asset in dealing with chronic illnesses such as acromegaly where quality of life is altered even after remission. However, it has been shown that quality of life of caregivers can also be impacted. Our main objective was to explore the consequences of acromegaly in remission in the patient-relative dyad in a matter of quality of life and self-esteem.MethodsIn this French m...

ea0090p369 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Impact of exenatide on weight loss and eating behavior in adults with craniopharyngioma-related obesity: the Cranioexe randomized placebo-controlled trial

Gatta-Cherifi Blandine , Mohammedi Kamel , Cariou Tanguy , Poitou-Bernert Christine , Touraine Philippe , Raverot Gerald , Brue Thierry , Chanson Philippe , Illouz Frederic , Solange Grunenwald , Chabre Olivier , Sonnet Emmanuel , Cuny Thomas , Bertherat Jerome , Czernichow Sebastien , Frison Eric , Tabarin Antoine

Background: Hyperphagia leading to craniopharyngioma-related obesity (CRO) is a common and serious sequel of treatments of craniopharyngiomas. The few therapeutic approaches that have been tested until now for the control of eating behaviour and weight have poor efficacy. Glucagon-like peptide-1 (GLP-1) analogues might be an option. Methods: This multicentre, randomised, double-blind superiority trial was conducted in France. Adults with CRO (BMI > 3...