Searchable abstracts of presentations at key conferences in endocrinology

ea0020p582 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Immunoassay determination of macroprolactin in hyperprolactinemic patients: an interassay comparative study

Martinho Mariana , Martinho Teresa , Cunha Nuno , Curado Fatima , Gomes Leonor , Valido Frederico , Naidenov Plamen , Rodrigues Fernando

Prolactin is mainly found in the monomeric form although it can also occur in the big-PRL and bigbigPRL (bbPRL) form: a complex of prolactin and immunoglobulin G. The latter has reduced bioactivity despite maintaining its imunorreactivity. This can cause false positive results representing the main cause of interassay variability in prolactin measurement. It should therefore be considered in every study concerning hyperprolactinemia. We aimed to evaluate the prevalence of bbPR...