Searchable abstracts of presentations at key conferences in endocrinology

ea0056ep1 | Adrenal and Neuroendocrine Tumours | ECE2018

Is pheochromocytoma a diagnostics chameleon indeed? Series of cases

Juszczyszyn Marta , Papierska Lucyna , Cwikla Jaroslaw , Zgliczynski Wojciech

Presence of clinical symptoms and signs specific for suspected illness is, in general, a condition sine qua non to start diagnostics procedures. However, some diseases may proceed with various and disparate symptoms, which often suggests completely different diagnosis. One of them is pheochromocytoma – rare, usually benign neoplasm derived from chromaffin cells of adrenal medulla. It is very important to diagnose the disease while it is curable by surgery like ma...

ea0041ep9 | Adrenal cortex (to include Cushing's) | ECE2016

The use of [131I] 6β-iodomethyl-norcholesterol scintigraphy in evaluation of adrenal tumors

Papierska Lucyna , Rabijewski Michal , Kaminska Anna , Cwikla Jaroslaw , Otto Maciej , Cichocki Andrzej , Samsel Radoslaw , Zgliczynski Wojciech

Adrenal cortex scintigraphy has been used as early as in the 1970s, however, in recent years, it has been a rarely performed and unappreciated examination. In fact, this examination does not provide a perfect view on morphology of adrenal glands, however it provides an assessment of the examined tumor’s function. The aim of this work is to present our experience with adrenal cortex scintigraphy in assessment of adrenal tumors.We present a series of ...

ea0035p25 | Adrenal cortex | ECE2014

Subclinical hypercortisolemia: who should be operated?

Papierska Lucyna , Cwikla Jaroslaw , Rabijewski Michal , Glinicki Piotr , Otto Maciej , Kasperlik-Zaluska Anna

Objective: According to some authors a higher incidence of subclinical hypercortisolaemia is found among patients with bilateral adrenal tumors with benign phenotype than with unilateral ones. The question is whether all patients with bilateral adrenal tumors and subclinical hypercortisolemia should undergo surgery and, if yes, which of the tumors should be removed first.Patients and methods: The investigated group consisted of 25 patients with benign bi...

ea0035p610 | Endocrine tumours and neoplasia | ECE2014

The value of parathyroid hormone determination in ultrasound-guided fine-needle aspirates (FNA–PTH) for preoperative localization of parathyroid lesions.

Kochman Magdalena , Misiorowski Waldemar , Papierska Lucyna , Stachlewska-Nasfeter Elzbieta , Chudzinski Witold , Cwikla Jaroslaw

Introduction: Ultrasound imagining of parathyroid lesions is often challenging, as they may be difficult to distinguish from thyroid lesions or enlarged lymph nodes.Aim: The aim of the study was to assess the value of parathyroid hormone determination in ultrasound-guided fine-needle aspirates-(FNA) in preoperative localization of parathyroid lesions.Materials and methods: We measured FNA–PTH in 30 consecutive patients with pr...

ea0014p474 | (1) | ECE2007

Extreme obesity as an important obstacle in diagnosing a patient with MEN1

Witek Przemyslaw , Zgliczynski Wojciech , Zdunowski Piotr , Cichocki Andrzej , Cwikla Jaroslaw B.

Background: MEN1 is an autosomal dominant inherited syndrome. Primary hyperparathyroidism, tumors of the endocrine pancreas, and of the pituitary, are the characteristic features of the syndrome.Objective: To present a case of MEN1 in a patient with extreme obesity, causing serious difficulties in diagnostic procedures leading to localization of pancreatic tumors.Case presentation: 22-year-old male with extreme obesity (BMI 59), hy...

ea0060p15 | (1) | UKINETS2018

NETest liquid biopsy is diagnostic of lung neuroendocrine tumors and identifies progressive disease

Malczewska Anna , Kos-Kudla Beata , Filosso Pier-Luigi , Aslanian Harry , Lewczuk Anna , Cwikla Jaroslaw , Rofinella Mateo , Bodei Lisa

Background: There are no effective blood biomarkers for bronchopulmonary carcinoids (BPC). We examined the utility of a neuroendocrine multigene transcript ‘liquid biopsy’ (NETest) in bronchopulmonary carcinoids (BPC) for diagnosis and monitoring of disease status.Aim: To independently validate the utility of the NETest in diagnosis and management of BPC in a prospective multicenter, multinational blinded study.Material a...

ea0035p578 | Endocrine tumours and neoplasia | ECE2014

Antiproliferative effects of lanreotide Autogel in patients with enteropancreatic neuroendocrine tumours: results of CLARINET, a large international phase 3 study

Caplin Martyn , Ruszniewski Philippe , Pavel Marianne , Cwikla Jaroslaw , Phan Alexandria , Raderer Markus , Sedlackova Eva , Cadiot Guillaume , Wall Lucy , Rindi Guido , Langley Alison , Blumberg Joelle

Introduction: Data demonstrating antiproliferative effects of somatostatin analogs (SSAs) in enteropancreatic NETs are limited; only one prospective trial so far has shown this for patients with midgut tumors and low hepatic tumor load (HTL). CLARINET is the first large phase 3, randomized, placebo-controlled trial evaluating such effects for the SSA lanreotide in patients with non-functioning enteropancreatic NETs.Methods: Patients who had well/moderate...

ea0014p133 | (1) | ECE2007

Adrenal incidentaloma, an oncological or endocrinological enigma? Clinical analysis of 1300 cases observed at a single endocrinological centre

Kasperlik-Zaluska Anna , Roslonowska Elzbieta , Slowinska-Srzednicka Jadwiga , Zgliczynski Wojciech , Jeske Wojciech , Papierska Lucyna , Otto Maciej , Slapa Rafal , Cichocki Andrzej , Cwikla Jaroslaw

Objective: Incidentally found adrenal tumour (adrenal incidentaloma = AI) is the most frequent adrenal disorder. Every patient with AI has to be evaluated carefully to choose the best method of management. We present our experience with a group of 1300 patients with AI, registered at our department.Material and methods: Material consisted of 1300 patients (female/male ratio 2.6, age 10–87 years) with AI ranging in size from 0.8 to 23.0 cm. Methods: ...

ea0052oc1 | (1) | UKINETS2017

A predictive quotient index, comprising neuroendocrine gene cluster analysis in blood and tissue grading is specifically predicts PRRT efficacy

Bodei Lisa , Kidd Mark , van der Zwaan Wouter , Singh Aviral , Severi Stefano , Drozdov Ignat , Kwekkeboom Dik , Cwikla Jaroslaw , Kolasinska-Cwikla Agnieska , Baum Richard P , Paganelli Giovanni , Krenning Eric , Modlin Irvin M

Background: The efficacy of PRRT is based upon NET over expression of somatostatin receptor (SSR) to deliver targeted isotope therapy. SSR expression (Krenning scale) compared to Predictive Quotient Index (PQI) (circulating NET transcript analysis mathematically integrated with grade) indicates the latter is more accurate for predicting PRRT efficacy. We evaluated whether PQI was specifically predictive or was prognostic for PRRT compared to other therapeutic strategi...

ea0052p02 | (1) | UKINETS2017

Validation of a blood biomarker test for the diagnosis and management of bronchopulmonary neuroendocrine tumors

Modlin Irvin , Kidd Mark , Lewczuk Anna , Chung Kjung-Min , Kolasinska-Cwikla Agnieska , Cwikla Jaroslaw , Lowczak Anna , Doboszynska Anna , Tesselaar Margot , Buikhuisen Wieneke , Malczewska Anna , Kos-Kudla Beata , Roffinella Matteo , Filosso Pier Luigi , Korse Tiny , Papotti Mauro , Bodei Lisa , Drozdov Ignat

Background: There is currently no effective blood biomarker for lung neuroendocrine neoplasia diagnosis and management. We describe the clinical utility of a 51 neuroendocrine-specific gene expression set in blood to diagnose bronchopulmonary neuroendocrine tumors (BPNETs) and define their clinical status.Methods: The discovery set included BPNETs (n=154) and controls (n=90), randomly assigned (1:1) to a test and validation set. Specifi...