ea0063p1148 | Reproductive Endocrinology 2 | ECE2019
Piot Anne
, Plotton Ingrid
, Dancer Benoite
, Bacchetta Justine
, Ailloud Sylviane
, Lejeune Herve
, Chapurlat Roland
, Szulc Pawel
, Confavreux Cyrille
Background: Klinefelter Syndrome (KS) patients, defined by a 47 XXY karyotype, suffer from osteoporosis, with an increased risk of mortality after femoral neck fracture. The mechanisms underlying this bone alteration remain unclear.Patients and methods: In KS patients naïve from testosterone substitution therapy (TST), we assessed bone microarchitecture at distal radius and tibia by High Resolution peripheral Computed Quantitative Tomography, and bo...