Searchable abstracts of presentations at key conferences in endocrinology

ea0035p1121 | Thyroid Cancer | ECE2014

The role of microRNAs in regulation of RARβ and its function in development of papillary thyroid carcinoma

Czajka Agnieszka , Wojcicka Anna , Stachlewska Elzbieta , Wiechno Wieslaw , Niewinski Grzegorz , Jazdzewski Krystian

Objectives: Papillary thyroid carcinoma (PTC) exhibits aberrant expression of retinoic acid receptor β (RARβ), a retinoic acid-inducible transcription factor, essential for cellular growth and development. The mechanisms leading to decreased RARβ expression in tumors are unknown. We hypothesized that changes in expression of RARB, a gene encoding for RARβ, result from aberrant expression of microRNAs. We elucidated the miRNome of normal thyroid and...

ea0035p1129 | Thyroid Cancer | ECE2014

The role of ATM–CHEK2–BRCA1 axis in determination of genetic predisposition and clinical presentation of papillary thyroid carcinoma

Wojcicka Anna , Czetwertynska Malgorzata , Swierniak Michal , Dlugosinska Joanna , Maciag Monika , Czajka Agnieszka , Dymecka Kinga , Kot Adam , Ploski Rafal , Jazdzewski Krystian

Background: Risk of developing papillary thyroid carcinoma (PTC), the most frequent thyroid malignancy, is elevated up to 8.6-fold in the first-degree relatives of PTC patients, what could be explained by polygenic action of low-penetrance alleles. Since the DNA-damaging exposure to ionizing radiation is a known risk factor for thyroid cancer, polymorphisms in DNA repair genes are likely to affect this risk. Among the DNA repair proteins, the ATM–CHEK2–BRCA1 axis see...