Searchable abstracts of presentations at key conferences in endocrinology

ea0022p837 | Thyroid | ECE2010

Prevalence of associated thyroid pathologies in patients with thyroid hemiagenesis and normally developed thyroid gland

Szczepanek Ewelina , Ruchala Marek , Czarnywojtek Agata , Sowinski Jerzy

Introduction: Thyroid hemiagenesis (TH) is a rare inborn anomaly occurring if one of the thyroid lobes fails to develop. Due to limited literature data and lack of large-cohort case–control studies, the clinical significance and management with patients in whom TH was diagnosed, are still a matter of debate. The objective of the study was a complex analysis of a large group of patients with TH in comparison to a control group of subjects born with normal, bilobed thyroid ...

ea0016p743 | Thyroid | ECE2008

Analysis of concomitant thyroid pathology in patients with thyroid hemiagenesis

Ruchala Marek , Szczepanek Ewelina , Zamyslowska Hanna , Czarnywojtek Agata , Sowinski Jerzy

Introduction: Thyroid hemiagenesis (TH) is a rare inborn anomaly of unclear importance. The aim of the study is to describe clinical, hormonal and autoimmunological profile of patients with TH.Material and methods: The studied group consisted of 20 subjects (4 men), diagnosed of having TH at the age from 15 to 63. Laboratory tests, including measurement of serum concentration of thyroid-stimulating hormone (TSH), free thyroxine (FT4), free tri...

ea0016p745 | Thyroid | ECE2008

Surgery, antithyroid drugs, or glucocorticosteriod in amioadarone-induced hyperthyroidism (AIH) in patients with low iodine uptake: that is the question

Czarnywojtek Agata , Ruchala Marek , Czepczynski Rafal , Szczepanek Ewelina , Sowinski Jerzy

Amiodarone is frequently used in cardiac patients but has side effects which effects the thyroid due to its high iodine content. The use of radioiodine in AIH with low iodine uptake is controversial. In these patients therapeutic choices for refractory cases include either: surgery, antithyroid drugs, or glucocorticosteriods.What are the treatment choices in elderly patients which can’t be operated on, agranulocytosis is present, or have toxic liver...

ea0049gp220 | Thyroid 3 | ECE2017

Analysis of a large cohort of subjects with thyroid hemiagenesis (THA) reveals random seasonality in the dates of birth

Szczepanek-Parulska Ewelina , Zybek-Kocik Ariadna , Niedziela Marek , Czarnywojtek Agata , Ruchala Marek

Introduction: In the etiology of thyroid dysgenesis (TD) an interplay between genetic and environmental factors is thought to play a crucial role. Data from previous studies on association between the season of birth and the incidence of TD causing congenital hypothyroidism (mainly agenesis and ectopy) are conflicting. To date, seasonality of births have not been analysed yet in regard to congenital absence of one thyroid lobe (thyroid hemiagenesis, THA).<p class="abstext"...

ea0016p758 | Thyroid | ECE2008

Visual evoked potentials in diagnosis of orbitopathy during the course of Graves-disease

Zgorzalewicz-Stachowiak Malgorzata , Czarnywojtek Agata , Bartkowiak Zuzanna , Komar-Rychlicka Krzesislawa , Sowinski Jerzy

Graves disease (GD) is autoimmunological disorder leading most often to hyperthyroidism and invasive-edema opthalmopathy (Graves opthalmopathy – GO).Aim: Estimation of the relation of visual evoked potentials (VEP) results with the indicators of activity and advancement of the progress of GO.Materials and methods: The examined group consisted of 45 patients between the age of 24 and 77, hospitalized in the Department of Endocr...

ea0049ep1275 | Thyroid (non-cancer) | ECE2017

Nicotinamide phosphoribosyltransferase expression in thyroid glands of patients with Graves’ disease

Sawicka-Gutaj Nadia , Andrusiewicz Miroslaw , Czarnywojtek Agata , Waligorska-Stachura Joanna , Biczysko Maciej , Skrobisz Jerzy , Sowinski Jerzy , Ruchala Marek

Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) overexpression was reported in many autoimmune diseases. We have also found NAMPT overexpression in leukocytes of patients with Graves’ orbitopathy. Therefore, we aimed to analyze NAMPT expression level in thyroid gland of patients with Graves’ disease with orbitopathy and without orbitopathy, and in healthy thyroid gland. We have analyzed 80 thyroid tissue samples of patients who underwent th...

ea0070aep573 | Pituitary and Neuroendocrinology | ECE2020

The SAGIT instrument: Potential utility in treatment decision-making in acromegaly

Sawicka-Gutaj Nadia , Ziółkowska Paulina , Ziemnicka Katarzyna , Szczepanek-Parulska Ewelina , Czarnywojtek Agata , Ruchała Marek

Introduction: The SAGIT instrument was developed for clinicians to assess the status and evolution of the disease in patients with acromegaly. Currently, it is investigated in the validation phase. The aim of our study was to evaluate the potential utility of SAGIT instrument for distinguishing acromegaly clinical stages and its usefulness in treatment decision-making at a single Polish endocrine center.Patients and Methods: Medical charts of adults with...

ea0026p432 | Thyroid (non cancer) | ECE2011

The influence of radioiodine therapy on ophthalmologic symptoms and their relation to urine cotinine level in patients with Graves’ disease

Czarnywojtek Agata , Ruchala Marek , Czepczynski Rafal , Szczepanek Ewelina , Florek Ewa , Zamyslowska Hanna , Kulinska-Niedziela Izabela , Komar-Rychlicka Krzesislawa , Sowinski Jerzy

Introduction: Radioiodine therapy (RIT) in patients with Graves’ disease (GD) and orbitopathy (GO) is still controversial, especially in smokers, due to the risk of exacerbation of ophthalmologic symptoms.Aim: To evaluate the effect of RIT in smoking and non-smoking patients with mild GO in a 6-month follow-up.Patients and methods: We examined 26 smoking and 25 non-smoking patients, matched for age and gender, presenting hyper...

ea0063gp184 | Benign Thyroid Disorders | ECE2019

Effect of restoration of thyroid function on body composition, insulin resistance and visfatin concentrations in women with hypo- and hyperthyroidism

Sawicka-Gutaj Nadia , Zybek-Kocik Ariadna , Kloska Michal , Czarnywojtek Agata , Sowiński Jerzy , Mańkowska-Wierzbicka Dorota , Ruchała Marek

Introduction: The adipose tissue secrets visfatin, that might have metabolic effect. Changes of visfatin serum concentrations have been observed in different thyroid pathologies. Thyroid hormones affect metabolism, thus, both hypo- and hyperthyroidism might significantly alter body composition.Aims of the study: We aimed to investigate the effect of restoration of euthyroidism on serum visfatin in severe thyroid dysfunction, and its associations with ins...

ea0041ep1073 | Thyroid (non-cancer) | ECE2016

Efficacy and safety of radioiodine therapy for mild Graves’ ophthalmopathy in dependence on nicotine consumption

Czarnywojtek Agata , Komar-Rychlicka Krzesislawa , Zgorzalewicz-Stachowiak Malgorzata , Wolinski Kosma , Stangierski Adam , Torlinska Barbara , Florek Ewa , Waligorska-Stachura Joanna , Ruchala Marek

Introduction: Graves ‘Orbitopathy (GO), is an autoimmune disease associated with Graves’ thyrotoxicosis (GT). The therapy is largely dependent on the severity and activity of ocular changes. Additionally, the severity of GO is influenced by exogenous factors, such as thyroid dysfunction, cigarette smoking or radioiodine therapy (RIT). The aim of the study was to indicate how radioiodine therapy (RIT) influences on GO in smoking and non-smoking patients.<p class="...