Searchable abstracts of presentations at key conferences in endocrinology

ea0035p1129 | Thyroid Cancer | ECE2014

The role of ATM–CHEK2–BRCA1 axis in determination of genetic predisposition and clinical presentation of papillary thyroid carcinoma

Wojcicka Anna , Czetwertynska Malgorzata , Swierniak Michal , Dlugosinska Joanna , Maciag Monika , Czajka Agnieszka , Dymecka Kinga , Kot Adam , Ploski Rafal , Jazdzewski Krystian

Background: Risk of developing papillary thyroid carcinoma (PTC), the most frequent thyroid malignancy, is elevated up to 8.6-fold in the first-degree relatives of PTC patients, what could be explained by polygenic action of low-penetrance alleles. Since the DNA-damaging exposure to ionizing radiation is a known risk factor for thyroid cancer, polymorphisms in DNA repair genes are likely to affect this risk. Among the DNA repair proteins, the ATM–CHEK2–BRCA1 axis see...

ea0035p591 | Endocrine tumours and neoplasia | ECE2014

Should unifocal papillary thyroid microcarcinoma be treated as much radically as multifocal one?

Guminska Anna , Bakula-Zalewska Elwira , Benke Malgorzata , Bruszewska Elzbieta , Czetwertynska Malgorzata , Dlugosinska Joanna , Garszel Anna , Godlewska Paulina , Musial Emilia , Niewiadomska Joanna , Dedecjus Marek

Introduction: Multifocal papillary thyroid microcarcinama (PTmC) has been considered as more aggressive than the unifocal one.Aim of the study: This paper aims to compare this two groups considering histopatological sign of aggressivity, presence of inflammation and radioiodine uptake.Materials and methods: The analysis concerned 81 patient with microcarcinoma (PTmC) selected from group of 961 (8%) diagnosed and treated in conventi...

ea0035p1139 | Thyroid Cancer | ECE2014

The effect of allelic variants of the thyroid hormone receptor β (THRB) gene on the incidence of papillary thyroid carcinoma

Wojcicka Anna , Roslon Marek , Czetwertynska Malgorzata , Swierniak Michal , Dlugosinska Joanna , Kot Adam , Ploski Rafal , Hromada-Judycka Aneta , Swiech Marta , Jazdzewski Krystian

Objectives: Papillary thyroid carcinoma (PTC) is the most common malignancy of the endocrine system. Its heritability is the highest among common cancers, as evidenced by family-based studies. Thyroid hormone receptor β gene (THRB), a known tumor suppressor, is crucial for the proper thyroid function, therefore its polymorphisms are likely to affect the risk for thyroid cancer.Aim of the study: In order to identify alleles that might modify...