Searchable abstracts of presentations at key conferences in endocrinology

ea0029p856 | Endocrine tumours and neoplasia | ICEECE2012

Performances of a new automated chromogranin-A assay

Gruson D. , Lepoutre T.

Background: Chromogranin A (CgA) is essential for the formation of secretory granules and sequestration of hormones in neuroendocrine cells. Measurement of CgA levels is included in the diagnostic procedure of neuroendocrine tumors and pheochromocytoma. The aim of this study was to assess the reliability of the Kryptor assay for CgA measurement.Methods: Imprecision of the Kryptor CgA assay was determined with two levels of CgA concentration. Reference va...

ea0029p106 | Adrenal cortex | ICEECE2012

Comparison of four immunoassays for measurement of cortisol levels

Gruson D. , Lepoutre T. , Galanti L.

Background: Measurement of serum cortisol levels can be useful in the diagnosis of conditions of both adrenal insufficiency and excess. Several methods are available for the measurement of the cortisol levels and immunoassays are commonly used in routine laboratories. The aim of our study was therefore to compare four different automated immunoassays for measurement of cortisol in serum.Methods: Serum samples of seventy two healthy volunteers were used f...

ea0029p1675 | Thyroid (non-cancer) | ICEECE2012

Measurement of TSH, FT4 and FT3 with immunoassays based on LOCI technology

Lepoutre T. , Daumerie C. , Gruson D.

Background: Measurements of TSH, free tetraiodothyronin (FT4) and triiodothyronin (FT3) are essential to achieve assessment of thyroid function. Luminescent Oxygen Channelling Immunoassays (LOCI) have recently been developed for the measurement of biomarkers of thyroid function. Such homogeneous immunoassays allow a faster delivery of the results. The aim of our study were therefore to determine the reference values for LOCI TSH, FT4 and FT<sub...

ea0097029 | Section | BES2023

Challenges in Pregnancy Diagnosis: A Case Report of Persistently Elevated hCG Levels

L Wauthier , L Courcelles , D Gruson

Serum or plasma human chorionic gonadotropin (hCG) immunoassays are a cornerstone in diagnosis and monitoring of pregnancy [1]. Although these assays show very satisfying performance, pathophysiological (e.g., menopause induced pituitary secretion of hCG, familial hCG syndrome, exogenous hCG injections) and analytical (e.g., interference of heterophilic antibodies or anti-hCG antibodies, lack of specificity of older assays) determinants may rarely cause false positive results ...