Searchable abstracts of presentations at key conferences in endocrinology

ea0011s99 | Metabolic syndrome | ECE2006

Insulin resistance and type 2 diabetes – insights from the study of extreme human phenotypes

Savage DB

Insulin resistance, which can be defined as a state of reduced responsiveness to normal circulating levels of insulin, plays a major role in the development of type 2 diabetes. Whilst standard definitions of insulin resistance still define it in terms of insulin’s effects on glucose metabolism, the last decade has seen a shift from the traditional ‘glucocentric’ view of diabetes to an increasingly acknowledged ‘lipocentric’ viewpoint. This hypothesis h...