ea0037oc5.2 | Steroids, developmental and paediatric endocrinology | ECE2015
Ansari Narjes Nasiri
, Spilioti Eliana
, Kalotychou Vasiliki
, Dalagiorgou Geena
, Moutsatsou Paraskevi
, Papavassiliou Athanasios
, Kassi Eva
Introduction: Glucocorticoids (GCs) are used in the treatment of chronic inflammatory or autoimmune diseases. However, patients are often resistant to the GC effects. Response to GCs is triggered through glucocorticoid receptor (GR). An important regulator of GR activity is the FKBP5. FKBP5 binds to co-chaperones promoting a conformation with lower cortisol affinity. The number of GRs is another determinant of GC sensitivity; GR expression is regulated by the nuclear ...