Searchable abstracts of presentations at key conferences in endocrinology

ea0014p128 | (1) | ECE2007

Expression of the neuropeptide cortistatin in haematological malignancies

Dalm Virgil , Staal Frank , Hofland Leo , van der Lely Aart-Jan , van Hagen Martin

Introduction: Cortistatin (CST) is a 17 amino-acid neuropeptide involved in sleep regulation. Due to its structural resemblance to somatostatin (SS), CST binds with high affinity to the 5 known SS receptors. CST also binds to the putative MrgX2 receptor. Previously we demonstrated that various types of human immune cells and tissues as well as lymphoid cell lines express CST mRNA. We suggested that CST plays a regulatory role in immune cell function both in physiological and p...