Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep249 | Calcium and Vitamin D metabolism | ECE2015

Analytical evaluation of a new fully automated immunoassay for the quantification of 1,25-dihydroxyvitamin D

Miller Nathalie , Gruson Damien

Background: Quantification of 1,25-dihydroxyvitamin D (1,25(OH)2D) remains challenging because of low circulating concentrations and potent cross-reactivities with steroid-like structures. The most frequent assays for 1,25(OH)2D testing are still based on RIA format with preliminary extraction. The analytical performances and the turnaround time of analysis (TAT) for these assays are limited. Several novel assays for 1,25(OH)2D testing are emer...

ea0032p29 | Adrenal cortex | ECE2013

Aldosterone measurement: performances of a new fully automated chemilunescence-based immunoassay

Gruson Damien , Lepoutre Thibault

Introduction: Measurement of aldosterone, the major mineralocorticoid secreted by adrenal cortex, is important for the screening of primary aldosteronism and for the clinical assessment of hypertensive patients. RIA remain widely used for the measurement of aldosterone but some automated immunoassays are emerging. The aim of our study was to evaluate the performances of a new automated aldosterone immunoassay.Methods: Method imprecision of the Liaison&#1...

ea0022p340 | Diabetes | ECE2010

Performances of the fully automated Liaison® system for determination of insulin and C-peptide concentrations

Gruson Damien , Preumont Vanessa , Vandeleene Bernard

Introduction: Circulating insulin levels are widely used to provide diagnostic information for diabetes mellitus and hypoglycaemic syndromes. C-peptide concentration provides an accurate assessment of residual B-cell function and reliable information about insulin secretion in patients with diabetes. The aim of this study was to evaluate the performances and reliability of the Liaison® fully automated system for measurement of insulin and C-peptide concentratio...

ea0032p148 | Calcium and Vitamin D metabolism | ECE2013

Measurement of 25-hydroxyvitamin D: evaluation of the new DIAsource ELISA assay

Huvelle Sophie , Lepoutre Thibault , Heureux Nicolas , Gruson Damien

Background: Vitamin D is an important contributor to musculoskeletal health and its potential involvement has recently been underlined in several non-skeletal diseases. Measurement of circulating levels of 25-hydroxyvitamin D (25OHD) represents the most reliable assessment of vitamin D status. Several assays are available but are not commutable because of a lack of of standardization. The aim of our study was to evaluate the performance of a new ELISA for measurement of 25OHD ...

ea0037ep97 | Steroids, development and paediatric endocrinology | ECE2015

Unusual presentation of the apparent mineralocorticoid excess, triggered by mild Cushing's disease in an adult

Zavratnik Andrej , Zavrsnik Matej , Ksela Urska , Homsak Evgenija , Rajic Antonela Sabati , Gruson Damien , Pfeifer Marija

Introduction: The syndrome of apparent mineralocorticoid excess (AME), a genetic disorder, resembles findings similar to those in primary aldosteronism, but aldosterone levels are low. AME is due to deficiency in the 11-beta-hydroxysteroid-dehydrogenase-enzyme-type-2 isoform (11-beta-HSD2), which normally converts cortisol to cortisone to prevent its mineralocorticoid activity at the aldosterone-sensitive sites. The deficiency in 11-beta-HSD2 leads to marked elevation in net m...

ea0070aep157 | Bone and Calcium | ECE2020

Burden of illness in patients with chronic hypoparathyroidism not adequately controlled with conventional therapy: A survey of physicians in belgium and the Netherlands

Hamdy Neveen AT , Decallonne Brigitte , Evenepoel Pieter , Gruson Damien , Marelli Claudio , van Vlokhoven-Verhaegh Liza

Patients with hypoparathyroidism are at risk of short-term and long-term complications and comorbidities, such as renal, cardiovascular, metabolic or cognitive manifestations. The purpose of this study was to determine the burden of illness (BOI) in patients with not adequately controlled chronic hypoparathyroidism receiving conventional therapy (oral calcium supplements and active vitamin D) in Belgium and the Netherlands. Data werecollected from a cross-sectional, 2-part onl...

ea0071014 | Influence of catecholamine secretory phenotype and preoperative alpha-blocker preparation on surgical outcome in pheochromocytoma | BES2020

Influence of catecholamine secretory phenotype and preoperative alpha-blocker preparation on surgical outcome in pheochromocytoma

Maria Furnica Raluca , Muddaththir Dusoruth Muhammad , Damien Gruson , Alexandre Persu , Michel Mourad , Dominique Maiter

Objectives: Surgery of pheochromocytomas (PC) still carries a high risk of hemodynamic complications during the perioperative period. We aimed to evaluate the influence of their secretory phenotype and preoperative alpha-blocker treatment on surgical outcome.Design: A retrospective monocentric study at a tertiary medical center.Patients: 80 consecutive patients operated for an adrenal PC between 1988 and 2018.<p class="abstext"...

ea0071017 | Biological variation and analytical goals of four thyroid function biomarkers in healthy European volunteers | BES2020

Biological variation and analytical goals of four thyroid function biomarkers in healthy European volunteers

Antoine Mairesse , Loris Wauthier , Louisiane Courcelles , Urszula Luyten , Maria-Cristina Burlacu , Diane Maisin , Julien Favresse , Marie-Astrid van Dievoet , Damien Gruson

Background: Interpretation of thyroid function tests by means of biological variation (BV) data is essential to identify significant changes between serial measurements at an individual level. Latest BV data on thyroid parameters in adults included in the EFLM Biological Variation Database have been published in 2008.Objectives: We aimed at determining the BV of four thyroid function test (thyroid-stimulating hormone (TSH), free thyrox...