Searchable abstracts of presentations at key conferences in endocrinology

ea0032p191 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Pentraxin-3 as a more sensitive marker of coronary artery disease severity than C-reactive protein

Szkodzinski Janusz , Hudzik Bartosz , Danikiewicz Aleksander , Pietka-Rzycka Anna , Lekston Andrzej , Zubelewicz-Szkodzinska Barbara

Introduction: Pentraxin-3 (PTX3) is an acute-phase reactant that shares structural and functional homology with C-reactive protein (CRP). However, unlike CRP, which is synthesized mainly in the liver, PTX3 is produced at the site of inflammation. It has been suggested that PTX3 plays the same role in the periphery that CRP does in circulation. PTX3 may represent a rapid marker for local inflammation.Methods: Fifty three patients with stable coronary arte...

ea0014p18 | (1) | ECE2007

Concentration of inflammatory factors such as CRP (acute phase response protein) and Interleukin (IL)-6 in serum patients with stable ischemic heart disease during trimetazidine treatment

Szkodzinski Janusz , Szewczyk Marek , Romanowski Wojciech , Danikiewicz Aleksander , Muc-Wierzgon Malgorzata , Zubelewicz-Szkodzinska Barbara

Background: The patomechanism of developing ischemic heart disease (i.h.d.) is stenosis of coronary blood vessels with plaque placed on vascular endothelium built with monocytes/macrophages, foam cells, oxidized LDL, leukocytes, platelets and collagen. Atherosclerotic lesions are heavily infiltrated by cellular components associated with inflammation and influenced by other inflammatory factors. Trimetazidine, a clinically effective antianginal agent acts by optimizing cardiac...

ea0070ep245 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Does 25-OH vitamin D concentration correlate with adipocytokines inpatients with non-functioning adrenal incidentalomas – preliminary study

Kowalska Joanna , Zielen-Zynek Iwona , Nowak Justyna , Hudzik Bartosz , Danikiewicz Aleksander , Szlacheta Patryk , Zubelewicz-Szkodzińska Barbara

Introduction: Vitamin D has pleiotropic effect on human body. Several studies showed that vitamin D deficiency has an influence on inflammation status in endocrine diseases (PCO-S, Graves disease, autoimmune endocrine disorders) and could reflect body fat tissue contain. Both, resistin and leptin, show pro-inflammatory effect.Aim: The aim of the study was to asses resistin and leptin serum concentration and its relationship with 25-OH vitamin D concentra...

ea0014p16 | (1) | ECE2007

Changes in growth hormone messenger RNA (GHmRNA) expression in rats anterior pituitary after single Interferon (IFN)alpha administration.

Romanowski Wojciech , Braczkowski Ryszard , Danikiewicz Aleksander , Nowakowska-Zajdel Ewa , Muc-Wierzgon Malgorzata , Muryn Zuzanna , Zubelewicz-Szkodzinska Barbara

Introduction: Interferon alpha (IFN alpha) is a cytokine with pleiotropic effects and via different pathways influences secretion of certain cytokines and hormones. Growth Hormone (GH) secreted from the pituitary has its physiological effects on various target tissues. The question is how IFN alpha administered in various type of diseases influences GH secretion. This study investigated acute effect of IFN-alpha on GH mRNA expression in rat anterior pituitary<p class="abst...

ea0070ep383 | Reproductive and Developmental Endocrinology | ECE2020

Could omentin concentration be an indicator of cardiovascular risk in PCO-S

Zielen-Zynek Iwona , Kowalska Joanna , Nowak Justyna , Kulik-Kupka Karolina , Korzonek-Szlacheta Ilona , Danikiewicz Aleksander , Hudzik Bartosz , Zubelewicz-Szkodzińska Barbara

Introduction: There have been described that about 50% of women diagnosed with PCO-S, present lipid metabolism disorders, insulin resistance and incorrect blood pressure. They suffer not only from fertility disorders, but also present a risk of metabolic complications such as: obesity, type 2 diabetes and hypertension, which increase diet-related cancers and cardiovascular risk.Aim: To explore if serum omentin concentration could be an indicator of cardi...