Endocrine Abstracts

This female patient presented acutely with headache and neck pain associated with vomiting. Neurological examination was normal. Urine pregnancy test prior to imaging was unexpectedly positive. CT head demonstrated a 2.5x1.5 cm hyperattenuating lesion at the left frontoparietal region. Thyroid function tests were in keeping with thyrotoxicosis (TSH <0.01 mU/l, free T4 37.2 pmo/l, free T3 >30.7 pmo/l). Antithyroid medication was commenced and TSH receptor antibody reque...

Case history: 80 year old male was referred to endocrine clinic for incidental hypercalcemia picked up on six monthly blood tests for follow up of treated carcinoma of prostate in remission. Patient himself complained only of mild mechanical backache and no other symptoms of hypercalcemia. There was no family history of thyroid or parathyroid related disorders. Drug history did not include thiazides or lithium. Investigations: serum calcium 2.75 mmol/l, ...

Case History: 27 year old female was referred to endocrine clinic with complaints of excess hirsutism over face, chin and neck accompanied with oligomenorrhea and acne for three years. The hirsutism was worsening gradually and she had to shave or wax her facial hair on daily basis. She was born at full term and had menarche at 12 to 13 years of age with regular periods. She had no symptoms of galactorrhea, headache, visual problems or recent weight gain. There was no family hi...

Case history: A 53 year old lady was admitted with aggressive behaviour and confusion. Past medical history: Treated breast cancer 2017, no recurrence on mammogram 2021. Lifelong smoker. Initial investigations: persistent hypokalaemia with metabolic alkalosis, negative septic screen, unremarkable CT and MRI brain, failed lumbar puncture. Hypokalaemia only corrected with SandoK and spironolactone. She was empirically treated for encephalitis. CT TAP (septic screen): extensive m...

A 69-year-old South Asian male presented in A+E with hyponatremia. He had pervious history of Lyme Node TB (treated 2014), Asthma and Nasal Polyps. Medication history, patient was taking Fludrocortisone nasal spray for the 30–40 years and Seretide inhaler. Also, CT scans at admission did not identify relapse in Lyme Node TB. Upon investigation he was found to have undetectable morning cortisol (<28 mmols). He was started on Hydrocortisone 10 mg, 5 mg and 5 mg regime, ...

We report a case of a 51 year-old gentleman with increased serum creatine kinase (CK) due to hypocalcaemic tetany caused by idiopathic hypoparathyrodism. Raised CK (1738 u/L) was incidentally noted in this patient by his GP. He had ongoing symptoms of hypocalcaemia with intermittent tetanic spasms in his hands and scalp and easy fatigability for 2 years. His examination showed normal stature, no evidence of myopathy with normal deep tendon reflexes, Trousseau’s sign was p...

A 20-year-old female admitted under haematology team for acute myeloid leukaemia. During her admission, she had a whole body CT scan and was found to have a left breast lesion (proven on biopsy to have invasive ductal carcinoma) and a right adrenal mass measuring 6.5 × 7.5 cm with radiological features suggestive of an adrenocortical cancer. Biochemical workup showed raised adrenal androgens: DHA Sulphate 14.9 umol/l (4.0–11.0), 17-OH Progesterone 7.6 nmol/l (0.6&#15...

Introduction: Osteogenesis imperfecta (OI) is a genetic, heterogeneous, connective tissue disorder most commonly caused by mutations in type I collagen genes. A hallmark of disease is frequent fractures that are precipitated by minimal trauma. There are limited data on the impact of OI on non-skeletal outcomes across the lifecourse. We present cross-sectional data of one of the largest single centre patient cohorts of OI in adulthood (n=186).The aim of this study was ...